ATXN1 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	-	uncharacterized LOC401442
Novel	ACACA	acetyl-CoA carboxylase alpha	ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine shuttle Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis	Biotin
Novel	ACOT7	acyl-CoA thioesterase 7	Mitochondrial Fatty Acid Beta-Oxidation
Novel	ADAM15	ADAM metallopeptidase domain 15	Degradation of the extracellular matrix Invadopodia formation
Novel	ADCY6	adenylate cyclase 6	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Colforsin
Novel	ADD3	adducin 3	Miscellaneous transport and binding events RHOD GTPase cycle RHOF GTPase cycle
Novel	AHDC1	AT-hook DNA binding motif containing 1
Novel	AKT1	AKT serine/threonine kinase 1	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Mitochondrial unfolded protein response (UPRmt) High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol Archexin Enzastaurin Perifosine N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine	PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
Novel	ANKHD1	ankyrin repeat and KH domain containing 1
Novel	ANP32A	acidic nuclear phosphoprotein 32 family member A	HuR (ELAVL1) binds and stabilizes mRNA
Novel	APBB1	amyloid beta precursor protein binding family B member 1	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Novel	ARHGAP32	Rho GTPase activating protein 32	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Novel	ARID5A	AT-rich interaction domain 5A
Novel	ASNS	asparagine synthetase (glutamine-hydrolyzing)	ATF4 activates genes in response to endoplasmic reticulum stress Aspartate and asparagine metabolism Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Aspartic acid Glutamic acid ATP Asparagine
Novel	ATF5	activating transcription factor 5	Response of EIF2AK1 (HRI) to heme deficiency Mitochondrial unfolded protein response (UPRmt) Mitochondrial unfolded protein response (UPRmt)	Pseudoephedrine
Novel	ATP1A3	ATPase Na+/K+ transporting subunit alpha 3	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Ouabain Bisacodyl Tegoprazan	Primary torsion dystonia (PTD)
Novel	ATP6V0D1	ATPase H+ transporting V0 subunit d1	ROS and RNS production in phagocytes XBP1(S) activates chaperone genes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Tiludronic acid
Novel	ATXN1L	ataxin 1 like
Novel	ATXN2	ataxin 2			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Novel	ATXN2L	ataxin 2 like

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