PTEN - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	MAST1	microtubule associated serine/threonine kinase 1		Fostamatinib
Novel	MAST2	microtubule associated serine/threonine kinase 2
Novel	MAST3	microtubule associated serine/threonine kinase 3
Novel	MATR3	matrin 3			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
Novel	MCM2	minichromosome maintenance complex component 2	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Novel	MCM3	minichromosome maintenance complex component 3	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Novel	MCM5	minichromosome maintenance complex component 5	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Novel	MCRS1	microspherule protein 1	HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes
Novel	MDC1	mediator of DNA damage checkpoint 1	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Novel	MDN1	midasin AAA ATPase 1
Novel	METTL26	methyltransferase like 26
Novel	MEX3C	mex-3 RNA binding family member C	Antigen processing: Ubiquitination & Proteasome degradation
Novel	MKI67	marker of proliferation Ki-67
Novel	MME	membrane metalloendopeptidase	Metabolism of Angiotensinogen to Angiotensins Physiological factors Neutrophil degranulation Developmental Lineage of Mammary Gland Myoepithelial Cells	Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat
Novel	MPRIP	myosin phosphatase Rho interacting protein	Signaling by BRAF and RAF1 fusions
Novel	MRPS22	mitochondrial ribosomal protein S22	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control		Combined oxidative phosphorylation deficiency (COXPD)
Novel	MRPS23	mitochondrial ribosomal protein S23	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Novel	MRPS27	mitochondrial ribosomal protein S27	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Novel	MRPS28	mitochondrial ribosomal protein S28	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Novel	MRPS7	mitochondrial ribosomal protein S7	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control

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