OGT - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
EIF3G	eukaryotic translation initiation factor 3 subunit G	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF4A1	eukaryotic translation initiation factor 4A1	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Copper
EIF4G2	eukaryotic translation initiation factor 4 gamma 2	ISG15 antiviral mechanism
EIF5	eukaryotic translation initiation factor 5	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
ELOA	elongin A	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
ENO1	enolase 1	Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
ERGIC3	ERGIC and golgi 3
ERI1	exoribonuclease 1	Major pathway of rRNA processing in the nucleolus and cytosol
ERO1A	endoplasmic reticulum oxidoreductase 1 alpha	Detoxification of Reactive Oxygen Species
ERO1B	endoplasmic reticulum oxidoreductase 1 beta	Insulin processing	1-Ethyl-Pyrrolidine-2,5-Dione Flavin adenine dinucleotide
ESS2	ess-2 spliceosome associated protein
ETF1	eukaryotic translation termination factor 1	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Protein hydroxylation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
EWSR1	EWS RNA binding protein 1			Extraskeletal myxoid chondrosarcoma Myxoid liposarcoma Ewing's sarcoma Clear cell sarcoma of soft tissue
FAF2	Fas associated factor family member 2	Neutrophil degranulation RHOA GTPase cycle
FAM199X	family with sequence similarity 199, X-linked
FAM98A	family with sequence similarity 98 member A
FARSA	phenylalanyl-tRNA synthetase subunit alpha	Cytosolic tRNA aminoacylation	Phenylalanine
FDXR	ferredoxin reductase	Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR	Flavin adenine dinucleotide Nicotinamide adenine dinucleotide phosphate
FEN1	flap structure-specific endonuclease 1	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Removal of the Flap Intermediate from the C-strand PCNA-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate	Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
FH	fumarate hydratase	Citric acid cycle (TCA cycle) Mitochondrial protein degradation		Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency Multiple cutaneous and uterine leiomyomata Renal cell carcinoma

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