Search Results for: KEAP1

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  • mRNA decay by 5' to 3' exoribonuclease
  • mRNA decay by 5' to 3' exoribonuclease
  • mRNA Splicing - Major Pathway
MAD2L1 mitotic arrest deficient 2 like 1
  • Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
  • Inactivation of APC/C via direct inhibition of the APC/C complex
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • APC/C:Cdc20 mediated degradation of mitotic proteins
  • APC-Cdc20 mediated degradation of Nek2A
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • RHO GTPases Activate Formins
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCC MCC regulator of Wnt signaling pathway
MCMBP minichromosome maintenance complex binding protein
MLST8 MTOR associated protein MLST8
  • PIP3 activates AKT signaling
  • Macroautophagy
  • MTOR signalling
  • mTORC1-mediated signalling
  • HSF1-dependent transactivation
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • CD28 dependent PI3K/Akt signaling
  • VEGFR2 mediated vascular permeability
  • TP53 Regulates Metabolic Genes
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Regulation of TP53 Degradation
  • Regulation of PTEN gene transcription
  • Amino acids regulate mTORC1
  • High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
MYO7A myosin VIIA
  • The canonical retinoid cycle in rods (twilight vision)
  • Sensory processing of sound by inner hair cells of the cochlea
  • Sensory processing of sound by outer hair cells of the cochlea
  • Deafness, autosomal recessive
  • Usher syndrome (US)
  • Deafness, autosomal dominant
NFE2L2 NFE2 like bZIP transcription factor 2
  • Neddylation
  • Potential therapeutics for SARS
  • Regulation of HMOX1 expression and activity
  • Heme signaling
  • KEAP1-NFE2L2 pathway
  • KEAP1-NFE2L2 pathway
  • Nuclear events mediated by NFE2L2
  • GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
  • NFE2L2 regulating TCA cycle genes
  • NFE2L2 regulating inflammation associated genes
  • NFE2L2 regulating anti-oxidant/detoxification enzymes
  • NFE2L2 regulates pentose phosphate pathway genes
  • NFE2L2 regulating tumorigenic genes
  • NFE2L2 regulating MDR associated enzymes
  • NFE2L2 regulating ER-stress associated genes
  • Regulation of NFE2L2 gene expression
  • Regulation of NFE2L2 gene expression
  • Regulation of PD-L1(CD274) transcription
NIBAN2 niban apoptosis regulator 2
NTAQ1 N-terminal glutamine amidase 1
NUDT4 nudix hydrolase 4
  • Synthesis of pyrophosphates in the cytosol
NUP50 nucleoporin 50
  • ISG15 antiviral mechanism
  • Transport of the SLBP independent Mature mRNA
  • Transport of the SLBP Dependant Mature mRNA
  • Transport of Mature mRNA Derived from an Intronless Transcript
  • Transport of Mature mRNA derived from an Intron-Containing Transcript
  • Rev-mediated nuclear export of HIV RNA
  • Transport of Ribonucleoproteins into the Host Nucleus
  • NS1 Mediated Effects on Host Pathways
  • Viral Messenger RNA Synthesis
  • NEP/NS2 Interacts with the Cellular Export Machinery
  • Regulation of Glucokinase by Glucokinase Regulatory Protein
  • Nuclear import of Rev protein
  • Vpr-mediated nuclear import of PICs
  • IPs transport between nucleus and cytosol
  • IP3 and IP4 transport between cytosol and nucleus
  • IP6 and IP7 transport between cytosol and nucleus
  • snRNP Assembly
  • SUMOylation of DNA damage response and repair proteins
  • SUMOylation of ubiquitinylation proteins
  • Nuclear Pore Complex (NPC) Disassembly
  • Regulation of HSF1-mediated heat shock response
  • SUMOylation of SUMOylation proteins
  • SUMOylation of chromatin organization proteins
  • SUMOylation of RNA binding proteins
  • SUMOylation of DNA replication proteins
  • SUMOylation of DNA replication proteins
  • Transcriptional regulation by small RNAs
  • Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
  • tRNA processing in the nucleus
  • HCMV Early Events
  • HCMV Late Events
  • SARS-CoV-2 activates/modulates innate and adaptive immune responses
OXR1 oxidation resistance 1
PAK1 p21 (RAC1) activated kinase 1
  • Generation of second messenger molecules
  • Regulation of actin dynamics for phagocytic cup formation
  • FCERI mediated MAPK activation
  • FCERI mediated MAPK activation
  • CD28 dependent Vav1 pathway
  • EPHB-mediated forward signaling
  • Ephrin signaling
  • Sema3A PAK dependent Axon repulsion
  • Activation of RAC1
  • Signal transduction by L1
  • Smooth Muscle Contraction
  • VEGFR2 mediated vascular permeability
  • CD209 (DC-SIGN) signaling
  • RHO GTPases activate PKNs
  • RHO GTPases Activate ROCKs
  • RHO GTPases activate PAKs
  • RHO GTPases activate PAKs
  • MAPK6/MAPK4 signaling
  • G beta:gamma signalling through CDC42
  • CDC42 GTPase cycle
  • RAC1 GTPase cycle
  • RAC2 GTPase cycle
  • RHOQ GTPase cycle
  • RHOH GTPase cycle
  • RHOJ GTPase cycle
  • RHOU GTPase cycle
  • RAC3 GTPase cycle
  • RHOV GTPase cycle
  • Fostamatinib
PANX1 pannexin 1
  • Electric Transmission Across Gap Junctions
  • The NLRP3 inflammasome
  • High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
  • Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
  • Probenecid
PAQR4 progestin and adipoQ receptor family member 4
PDCD6IP programmed cell death 6 interacting protein
  • Budding and maturation of HIV virion
  • Uptake and function of anthrax toxins
  • RIPK1-mediated regulated necrosis
  • Regulation of necroptotic cell death
PLEC plectin
  • Assembly of collagen fibrils and other multimeric structures
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Type I hemidesmosome assembly
  • Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
  • Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1
  • Translocation of SLC2A4 (GLUT4) to the plasma membrane
  • Macroautophagy
  • Activation of PPARGC1A (PGC-1alpha) by phosphorylation
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • TP53 Regulates Metabolic Genes
  • Regulation of TP53 Activity through Phosphorylation
  • Lipophagy
  • Activation of AMPK downstream of NMDARs
  • AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
  • Adenosine phosphate
  • Acetylsalicylic acid
  • Fostamatinib
PTMA prothymosin alpha

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