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LSM3 |
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated |
- mRNA decay by 5' to 3' exoribonuclease
- mRNA decay by 5' to 3' exoribonuclease
- mRNA Splicing - Major Pathway
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MAD2L1 |
mitotic arrest deficient 2 like 1 |
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
- Inactivation of APC/C via direct inhibition of the APC/C complex
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- APC/C:Cdc20 mediated degradation of mitotic proteins
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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MAPKBP1 |
mitogen-activated protein kinase binding protein 1 |
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MCC |
MCC regulator of Wnt signaling pathway |
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MCMBP |
minichromosome maintenance complex binding protein |
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MLST8 |
MTOR associated protein MLST8 |
- PIP3 activates AKT signaling
- Macroautophagy
- MTOR signalling
- mTORC1-mediated signalling
- HSF1-dependent transactivation
- Energy dependent regulation of mTOR by LKB1-AMPK
- CD28 dependent PI3K/Akt signaling
- VEGFR2 mediated vascular permeability
- TP53 Regulates Metabolic Genes
- Constitutive Signaling by AKT1 E17K in Cancer
- Regulation of TP53 Degradation
- Regulation of PTEN gene transcription
- Amino acids regulate mTORC1
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
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MYO7A |
myosin VIIA |
- The canonical retinoid cycle in rods (twilight vision)
- Sensory processing of sound by inner hair cells of the cochlea
- Sensory processing of sound by outer hair cells of the cochlea
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- Deafness, autosomal recessive
- Usher syndrome (US)
- Deafness, autosomal dominant
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NFE2L2 |
NFE2 like bZIP transcription factor 2 |
- Neddylation
- Potential therapeutics for SARS
- Regulation of HMOX1 expression and activity
- Heme signaling
- KEAP1-NFE2L2 pathway
- KEAP1-NFE2L2 pathway
- Nuclear events mediated by NFE2L2
- GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
- NFE2L2 regulating TCA cycle genes
- NFE2L2 regulating inflammation associated genes
- NFE2L2 regulating anti-oxidant/detoxification enzymes
- NFE2L2 regulates pentose phosphate pathway genes
- NFE2L2 regulating tumorigenic genes
- NFE2L2 regulating MDR associated enzymes
- NFE2L2 regulating ER-stress associated genes
- Regulation of NFE2L2 gene expression
- Regulation of NFE2L2 gene expression
- Regulation of PD-L1(CD274) transcription
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NIBAN2 |
niban apoptosis regulator 2 |
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NTAQ1 |
N-terminal glutamine amidase 1 |
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NUDT4 |
nudix hydrolase 4 |
- Synthesis of pyrophosphates in the cytosol
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NUP50 |
nucleoporin 50 |
- ISG15 antiviral mechanism
- Transport of the SLBP independent Mature mRNA
- Transport of the SLBP Dependant Mature mRNA
- Transport of Mature mRNA Derived from an Intronless Transcript
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- Rev-mediated nuclear export of HIV RNA
- Transport of Ribonucleoproteins into the Host Nucleus
- NS1 Mediated Effects on Host Pathways
- Viral Messenger RNA Synthesis
- NEP/NS2 Interacts with the Cellular Export Machinery
- Regulation of Glucokinase by Glucokinase Regulatory Protein
- Nuclear import of Rev protein
- Vpr-mediated nuclear import of PICs
- IPs transport between nucleus and cytosol
- IP3 and IP4 transport between cytosol and nucleus
- IP6 and IP7 transport between cytosol and nucleus
- snRNP Assembly
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of ubiquitinylation proteins
- Nuclear Pore Complex (NPC) Disassembly
- Regulation of HSF1-mediated heat shock response
- SUMOylation of SUMOylation proteins
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA replication proteins
- Transcriptional regulation by small RNAs
- Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
- tRNA processing in the nucleus
- HCMV Early Events
- HCMV Late Events
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
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OXR1 |
oxidation resistance 1 |
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PAK1 |
p21 (RAC1) activated kinase 1 |
- Generation of second messenger molecules
- Regulation of actin dynamics for phagocytic cup formation
- FCERI mediated MAPK activation
- FCERI mediated MAPK activation
- CD28 dependent Vav1 pathway
- EPHB-mediated forward signaling
- Ephrin signaling
- Sema3A PAK dependent Axon repulsion
- Activation of RAC1
- Signal transduction by L1
- Smooth Muscle Contraction
- VEGFR2 mediated vascular permeability
- CD209 (DC-SIGN) signaling
- RHO GTPases activate PKNs
- RHO GTPases Activate ROCKs
- RHO GTPases activate PAKs
- RHO GTPases activate PAKs
- MAPK6/MAPK4 signaling
- G beta:gamma signalling through CDC42
- CDC42 GTPase cycle
- RAC1 GTPase cycle
- RAC2 GTPase cycle
- RHOQ GTPase cycle
- RHOH GTPase cycle
- RHOJ GTPase cycle
- RHOU GTPase cycle
- RAC3 GTPase cycle
- RHOV GTPase cycle
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PANX1 |
pannexin 1 |
- Electric Transmission Across Gap Junctions
- The NLRP3 inflammasome
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
- Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
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PAQR4 |
progestin and adipoQ receptor family member 4 |
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PDCD6IP |
programmed cell death 6 interacting protein |
- Budding and maturation of HIV virion
- Uptake and function of anthrax toxins
- RIPK1-mediated regulated necrosis
- Regulation of necroptotic cell death
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PLEC |
plectin |
- Assembly of collagen fibrils and other multimeric structures
- Caspase-mediated cleavage of cytoskeletal proteins
- Type I hemidesmosome assembly
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- Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
- Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
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PRKAG1 |
protein kinase AMP-activated non-catalytic subunit gamma 1 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Macroautophagy
- Activation of PPARGC1A (PGC-1alpha) by phosphorylation
- Energy dependent regulation of mTOR by LKB1-AMPK
- TP53 Regulates Metabolic Genes
- Regulation of TP53 Activity through Phosphorylation
- Lipophagy
- Activation of AMPK downstream of NMDARs
- AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
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- Adenosine phosphate
- Acetylsalicylic acid
- Fostamatinib
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PTMA |
prothymosin alpha |
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