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PSME3 |
proteasome activator subunit 3 |
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RAD9A |
RAD9 checkpoint clamp component A |
- Activation of ATR in response to replication stress
- HDR through Single Strand Annealing (SSA)
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Impaired BRCA2 binding to RAD51
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RCHY1 |
ring finger and CHY zinc finger domain containing 1 |
- Translesion Synthesis by POLH
- Antigen processing: Ubiquitination & Proteasome degradation
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
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REV3L |
REV3 like, DNA directed polymerase zeta catalytic subunit |
- Translesion synthesis by REV1
- Translesion synthesis by POLK
- Translesion synthesis by POLI
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RHOBTB2 |
Rho related BTB domain containing 2 |
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RNF8 |
ring finger protein 8 |
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- G2/M DNA damage checkpoint
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SIAH2 |
siah E3 ubiquitin protein ligase 2 |
- Netrin-1 signaling
- Ub-specific processing proteases
- Amyloid fiber formation
- Antigen processing: Ubiquitination & Proteasome degradation
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SLC25A6 |
solute carrier family 25 member 6 |
- Mitochondrial protein import
- Mitochondrial protein import
- Influenza Virus Induced Apoptosis
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
- Mitochondrial protein degradation
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- Clodronic acid
- Etidronic acid
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SRPK1 |
SRSF protein kinase 1 |
- Maturation of nucleoprotein
- Replacement of protamines by nucleosomes in the male pronucleus
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SRPK2 |
SRSF protein kinase 2 |
- Maturation of nucleoprotein
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- Adenine
- Purvalanol
- Phosphoaminophosphonic Acid-Adenylate Ester
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ST14 |
ST14 transmembrane serine protease matriptase |
- Formation of the cornified envelope
- Formation of the cornified envelope
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- Urokinase
- Benzamidine
- Camostat
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- Ichthyosis with hypotrichosis
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STMN1 |
stathmin 1 |
- Nuclear signaling by ERBB4
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STRAP |
serine/threonine kinase receptor associated protein |
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- Positive Regulation of CDH1 Gene Transcription
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SUSD2 |
sushi domain containing 2 |
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TLR3 |
toll like receptor 3 |
- Trafficking and processing of endosomal TLR
- Toll Like Receptor 3 (TLR3) Cascade
- TICAM1, RIP1-mediated IKK complex recruitment
- RIP-mediated NFkB activation via ZBP1
- TLR3 deficiency - HSE
- UNC93B1 deficiency - HSE
- TICAM1 deficiency - HSE
- TRAF3 deficiency - HSE
- TLR3-mediated TICAM1-dependent programmed cell death
- TICAM1-dependent activation of IRF3/IRF7
- TICAM1,TRAF6-dependent induction of TAK1 complex
- Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
- RSV-host interactions
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TP53 |
tumor protein p53 |
- Activation of NOXA and translocation to mitochondria
- Activation of PUMA and translocation to mitochondria
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- Oncogene Induced Senescence
- DNA Damage/Telomere Stress Induced Senescence
- SUMOylation of transcription factors
- Autodegradation of the E3 ubiquitin ligase COP1
- Association of TriC/CCT with target proteins during biosynthesis
- Pyroptosis
- TP53 Regulates Metabolic Genes
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Interleukin-4 and Interleukin-13 signaling
- TP53 Regulates Transcription of DNA Repair Genes
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- TP53 Regulates Transcription of Caspase Activators and Caspases
- TP53 Regulates Transcription of Death Receptors and Ligands
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- Regulation of TP53 Expression
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Acetylation
- Regulation of TP53 Activity through Association with Co-factors
- Regulation of TP53 Activity through Methylation
- PI5P Regulates TP53 Acetylation
- G2/M DNA damage checkpoint
- G2/M Checkpoints
- Stabilization of p53
- Transcriptional activation of cell cycle inhibitor p21
- The role of GTSE1 in G2/M progression after G2 checkpoint
- Transcriptional Regulation by VENTX
- RUNX3 regulates CDKN1A transcription
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Loss of function of TP53 in cancer due to loss of tetramerization ability
- Signaling by ALK fusions and activated point mutants
- Regulation of NF-kappa B signaling
- Zygotic genome activation (ZGA)
- Factors involved in megakaryocyte development and platelet production
- PKR-mediated signaling
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- Acetylsalicylic acid
- Zinc
- Triethyl phosphate
- AZD 3355
- 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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- Chronic myeloid leukemia (CML)
- Breast cancer
- Non-small cell lung cancer
- Gastric cancer
- Adult T-cell leukemia
- Choriocarcinoma
- Esophageal cancer
- Glioma
- Pancreatic cancer
- Vulvar cancer
- Multiple myeloma
- Choroid plexus papilloma
- Ovarian cancer
- Hepatocellular carcinoma
- Squamous cell carcinoma
- Endometrial Cancer
- Penile cancer
- Cancer of the anal canal
- Hairy-cell leukemia
- Oral cancer
- Adrenal carcinoma
- Malignant melanoma
- Burkitt lymphoma
- Thyroid cancer
- Basal cell carcinoma
- Small cell lung cancer
- Gallbladder cancer
- Bladder cancer
- Laryngeal cancer
- Kaposi's sarcoma
- Cholangiocarcinoma
- Chronic lymphocytic leukemia (CLL)
- Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
- Malignant pleural mesothelioma
- Osteosarcoma
- Colorectal cancer
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TSSK1B |
testis specific serine kinase 1B |
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USP39 |
ubiquitin specific peptidase 39 |
- mRNA Splicing - Major Pathway
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VHL |
von Hippel-Lindau tumor suppressor |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- SUMOylation of ubiquitinylation proteins
- Neddylation
- Replication of the SARS-CoV-1 genome
- Replication of the SARS-CoV-2 genome
- RHOBTB3 ATPase cycle
- Antigen processing: Ubiquitination & Proteasome degradation
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- von Hippel-Lindau syndrome
- Congenital polycythemia; Familial erythrocytosis (ECYT)
- Renal cell carcinoma
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XRCC1 |
X-ray repair cross complementing 1 |
- Resolution of AP sites via the single-nucleotide replacement pathway
- APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
- HDR through MMEJ (alt-NHEJ)
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
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