ATXN1 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	NUDT21	nudix hydrolase 21	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Novel	NUMBL	NUMB like endocytic adaptor protein
Novel	NUTM2B	NUT family member 2B
Novel	OAZ1	ornithine decarboxylase antizyme 1	Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines	Ornithine
Novel	OPCML	opioid binding protein/cell adhesion molecule like	Post-translational modification: synthesis of GPI-anchored proteins
Novel	OTX2	orthodenticle homeobox 2	Formation of the anterior neural plate Formation of the posterior neural plate		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
Novel	PANX2	pannexin 2	Electric Transmission Across Gap Junctions
Novel	PEPD	peptidase D
Novel	PHPT1	phosphohistidine phosphatase 1
Novel	PIAS1	protein inhibitor of activated STAT 1	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling
Novel	PICALM	phosphatidylinositol binding clathrin assembly protein	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RND3 GTPase cycle
Novel	PIM2	Pim-2 proto-oncogene, serine/threonine kinase
Novel	PITX3	paired like homeodomain 3
Novel	PLA2G10	phospholipase A2 group X	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Novel	PLEKHB1	pleckstrin homology domain containing B1
Novel	PLEKHN1	pleckstrin homology domain containing N1
Novel	PML	PML nuclear body scaffold	SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events	Arsenic trioxide	Acute myeloid leukemia (AML)
Novel	POGZ	pogo transposable element derived with ZNF domain
Novel	POM121	POM121 transmembrane nucleoporin	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Novel	POMP	proteasome maturation protein	Proteasome assembly Proteasome assembly		Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome

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