Search Results for: APP

2116 interactions involving APP - amyloid beta precursor protein found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
ATL3 atlastin GTPase 3
ATOSB atos homolog B
ATP5F1A ATP synthase F1 subunit alpha
  • Mitochondrial protein import
  • Formation of ATP by chemiosmotic coupling
  • Cristae formation
  • Mitochondrial protein degradation
  • Quercetin
  • 1-ACETYL-2-CARBOXYPIPERIDINE
  • AUROVERTIN B
  • Piceatannol
  • N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
  • Artenimol
ATP5F1C ATP synthase F1 subunit gamma
  • Formation of ATP by chemiosmotic coupling
  • Cristae formation
  • Mitochondrial protein degradation
  • Quercetin
  • 1-ACETYL-2-CARBOXYPIPERIDINE
  • AUROVERTIN B
  • Piceatannol
  • N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
ATP5PD ATP synthase peripheral stalk subunit d
  • Formation of ATP by chemiosmotic coupling
  • Cristae formation
  • Mitochondrial protein degradation
ATP5PO ATP synthase peripheral stalk subunit OSCP
  • Formation of ATP by chemiosmotic coupling
  • Cristae formation
  • Mitochondrial protein degradation
  • Artenimol
ATP6V1E1 ATPase H+ transporting V1 subunit E1
  • ROS and RNS production in phagocytes
  • Insulin receptor recycling
  • Transferrin endocytosis and recycling
  • Amino acids regulate mTORC1
  • Ion channel transport
  • Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
  • Tiludronic acid
ATP6V1G1 ATPase H+ transporting V1 subunit G1
  • ROS and RNS production in phagocytes
  • Insulin receptor recycling
  • Transferrin endocytosis and recycling
  • Amino acids regulate mTORC1
  • Ion channel transport
  • Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
  • Tiludronic acid
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
  • Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
ATRAID all-trans retinoic acid induced differentiation factor
ATXN3 ataxin 3
  • Josephin domain DUBs
  • FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
  • Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
ATXN7L3 ataxin 7 like 3
  • HATs acetylate histones
AURKA aurora kinase A
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Regulation of PLK1 Activity at G2/M Transition
  • SUMOylation of DNA replication proteins
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
  • Regulation of TP53 Activity through Phosphorylation
  • FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
  • AURKA Activation by TPX2
  • Interaction between PHLDA1 and AURKA
  • Phosphonothreonine
  • AT9283
  • CYC116
  • Alisertib
  • SNS-314
  • Cenisertib
  • Enzastaurin
  • 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
  • AKI-001
  • 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea
  • 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea
  • N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE
  • N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide
  • 2-(1H-pyrazol-3-yl)-1H-benzimidazole
  • N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
  • Fostamatinib
  • MK-5108
  • MLN8054
AURKB aurora kinase B
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • SUMOylation of DNA replication proteins
  • RHO GTPases Activate Formins
  • Regulation of TP53 Activity through Phosphorylation
  • Mitotic Prometaphase
  • Regulation of MECP2 expression and activity
  • EML4 and NUDC in mitotic spindle formation
  • Hesperidin
  • AT9283
  • Enzastaurin
  • Reversine
  • Fostamatinib
  • TAK-901
AVPI1 arginine vasopressin induced 1
BAALC-AS2 BAALC antisense RNA 2
BACE1 beta-secretase 1
  • Amyloid fiber formation
  • MMI-175
  • CTS-21166
  • N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
  • N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE
  • N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
  • 4-(4-FLUOROBENZYL)PIPERIDINE
  • N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide
  • 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE
  • 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE
  • N~3~-BENZYLPYRIDINE-2,3-DIAMINE
  • N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
  • N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE
  • 4-(2-aminoethyl)-2-cyclohexylphenol
  • 4-(2-aminoethyl)-2-ethylphenol
  • 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine
  • (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
  • 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one
  • (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol
  • N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide
  • N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
  • (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
  • (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
  • N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
  • (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
  • N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE
  • N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE
  • 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
  • Verubecestat
BACE2 beta-secretase 2
BAIAP2 BAR/IMD domain containing adaptor protein 2
  • Regulation of actin dynamics for phagocytic cup formation
  • Regulation of actin dynamics for phagocytic cup formation
  • VEGFA-VEGFR2 Pathway
  • RHO GTPases Activate WASPs and WAVEs
  • RHO GTPases Activate WASPs and WAVEs
  • CDC42 GTPase cycle
  • RAC1 GTPase cycle
  • RAC3 GTPase cycle
  • FCGR3A-mediated phagocytosis
  • FCGR3A-mediated phagocytosis
BBX BBX high mobility group box domain containing

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