APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
SLC22A6	solute carrier family 22 member 6	Organic anion transport by SLC22 transporters	Cefotaxime Probenecid Ceftriaxone
SLC35B1	solute carrier family 35 member B1
SLC38A2	solute carrier family 38 member 2	Glutamate Neurotransmitter Release Cycle Amino acid transport across the plasma membrane	Asparagine
SLC41A3	solute carrier family 41 member 3
SLC48A1	solute carrier family 48 member 1
SLC4A1AP	solute carrier family 4 member 1 adaptor protein
SLC68A1	solute carrier family 68 member 1
SLC7A1	solute carrier family 7 member 1	Amino acid transport across the plasma membrane	Lysine Arginine Ornithine
SLCO2B1	solute carrier organic anion transporter family member 2B1	Organic anion transport by SLCO transporters	Gemfibrozil Telaprevir
SLFNL1	schlafen like 1
SLIT1-AS1	SLIT1 antisense RNA 1
SLX4	SLX4 structure-specific endonuclease subunit	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
SMAD1	SMAD family member 1	Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development Cardiogenesis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
SMAD3	SMAD family member 3	Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression
SMAP1	small ArfGAP 1
SMARCB1	SWI/SNF related BAF chromatin remodeling complex subunit B1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
SMG5	SMG5 nonsense mediated mRNA decay factor	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SMIM11	small integral membrane protein 11
SMTNL2	smoothelin like 2
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	Signaling by BMP Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Asymmetric localization of PCP proteins Hedgehog 'on' state Hedgehog 'on' state Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation

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