APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1	Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
SH3GLB1	SH3 domain containing GRB2 like, endophilin B1
SH3RF2	SH3 domain containing ring finger 2
SHANK3	SH3 and multiple ankyrin repeat domains 3	Neurexins and neuroligins Neurexins and neuroligins RET signaling
SHC1	SHC adaptor protein 1	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells
SHC3	SHC adaptor protein 3	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
SHMT2	serine hydroxymethyltransferase 2	Metabolism of folate and pterines RHOG GTPase cycle Mitochondrial protein degradation	Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
SHOC2	SHOC2 leucine rich repeat scaffold protein	RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
SIGIRR	single Ig and TIR domain containing	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling
SIK2	salt inducible kinase 2		Fostamatinib
SIRT5	sirtuin 5	Transcriptional activation of mitochondrial biogenesis	Adenosine-5-Diphosphoribose Nicotinamide 2'-O-Acetyl Adenosine-5-Diphosphoribose Suramin Cambinol
SIRT7	sirtuin 7
SIVA1	SIVA1 apoptosis inducing factor		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
SIX2	SIX homeobox 2	Formation of the ureteric bud
SKA3	spindle and kinetochore associated complex subunit 3
SKAP1	src kinase associated phosphoprotein 1
SKAP2	src kinase associated phosphoprotein 2	Signal regulatory protein family interactions
SLAIN2	SLAIN motif family member 2
SLC17A5	solute carrier family 17 member 5	Hyaluronan degradation Sialic acid metabolism Organic anion transport by SLC5/17/25 transporters Defective SLC17A5 causes Salla disease (SD) and ISSD		Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
SLC1A1	solute carrier family 1 member 1	Glutamate Neurotransmitter Release Cycle Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC-mediated transport of amino acids	Aspartic acid Glutamic acid	Dicarboxylic aminoaciduria

Search Results for: APP