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PBK |
PDZ binding kinase |
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PDCD6 |
programmed cell death 6 |
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- Calcium
- Zinc
- Calcium citrate
- Calcium Phosphate
- Calcium phosphate dihydrate
- Zinc acetate
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PDGFRA |
platelet derived growth factor receptor alpha |
- PIP3 activates AKT signaling
- Downstream signal transduction
- Signaling by PDGF
- Constitutive Signaling by Aberrant PI3K in Cancer
- RAF/MAP kinase cascade
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
- Signaling by PDGFRA extracellular domain mutants
- Imatinib-resistant PDGFR mutants
- Sunitinib-resistant PDGFR mutants
- Regorafenib-resistant PDGFR mutants
- Sorafenib-resistant PDGFR mutants
- PDGFR mutants bind TKIs
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- Becaplermin
- Imatinib
- Sunitinib
- XL820
- Olaratumab
- Pazopanib
- Midostaurin
- Regorafenib
- Ponatinib
- Lenvatinib
- Nintedanib
- Foreskin keratinocyte (neonatal)
- Tivozanib
- Fostamatinib
- Erdafitinib
- Amuvatinib
- Ripretinib
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PFDN1 |
prefoldin subunit 1 |
- Prefoldin mediated transfer of substrate to CCT/TriC
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PHF20L1 |
PHD finger protein 20 like 1 |
- Formation of WDR5-containing histone-modifying complexes
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PINX1 |
PIN2 (TERF1) interacting telomerase inhibitor 1 |
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PPIA |
peptidylprolyl isomerase A |
- Platelet degranulation
- Uncoating of the HIV Virion
- Budding and maturation of HIV virion
- Integration of provirus
- Early Phase of HIV Life Cycle
- Minus-strand DNA synthesis
- Plus-strand DNA synthesis
- Binding and entry of HIV virion
- Assembly Of The HIV Virion
- APOBEC3G mediated resistance to HIV-1 infection
- Calcineurin activates NFAT
- Basigin interactions
- Neutrophil degranulation
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
- SARS-CoV-1 activates/modulates innate immune responses
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- Cyclosporine
- Proline
- (3r)-1-Acetyl-3-Methylpiperidine
- Ethyl Oxo(Piperidin-1-Yl)Acetate
- Sanglifehrin A
- Copper
- Artenimol
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PRKCA |
protein kinase C alpha |
- Calmodulin induced events
- Disinhibition of SNARE formation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- Regulation of KIT signaling
- EGFR Transactivation by Gastrin
- Inactivation, recovery and regulation of the phototransduction cascade
- Syndecan interactions
- Acetylcholine regulates insulin secretion
- Ca2+ pathway
- Trafficking of GluR2-containing AMPA receptors
- G alpha (z) signalling events
- Depolymerization of the Nuclear Lamina
- HuR (ELAVL1) binds and stabilizes mRNA
- WNT5A-dependent internalization of FZD4
- VEGFR2 mediated cell proliferation
- RHO GTPases Activate NADPH Oxidases
- Response to elevated platelet cytosolic Ca2+
- RET signaling
- ROBO receptors bind AKAP5
- ROBO receptors bind AKAP5
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- Phosphatidyl serine
- Vitamin E
- Tamoxifen
- Staurosporine
- Dequalinium
- Ingenol mebutate
- Aprinocarsen
- Midostaurin
- Perifosine
- Ellagic acid
- Benzoyl peroxide
- Bryostatin 1
- alpha-Tocopherol succinate
- D-alpha-Tocopherol acetate
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PTGES3 |
prostaglandin E synthase 3 |
- Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
- HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
- HSF1 activation
- Attenuation phase
- Aryl hydrocarbon receptor signalling
- ESR-mediated signaling
- Estrogen-dependent gene expression
- Potential therapeutics for SARS
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- Acetaminophen
- Grn163l
- Copper
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PTMA |
prothymosin alpha |
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PTPA |
protein phosphatase 2 phosphatase activator |
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RAF1 |
Raf-1 proto-oncogene, serine/threonine kinase |
- Stimuli-sensing channels
- Rap1 signalling
- GP1b-IX-V activation signalling
- CD209 (DC-SIGN) signaling
- RAF activation
- MAP2K and MAPK activation
- Negative feedback regulation of MAPK pathway
- Negative regulation of MAPK pathway
- Signaling by moderate kinase activity BRAF mutants
- Signaling by high-kinase activity BRAF mutants
- Signaling by BRAF and RAF1 fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Signaling downstream of RAS mutants
- Signaling by RAF1 mutants
- SHOC2 M1731 mutant abolishes MRAS complex function
- Gain-of-function MRAS complexes activate RAF signaling
- IFNG signaling activates MAPKs
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- Sorafenib
- LErafAON
- XL281
- iCo-007
- Cholecystokinin
- Regorafenib
- Dabrafenib
- Fostamatinib
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RASSF1 |
Ras association domain family member 1 |
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- Nasopharyngeal cancer
- Non-small cell lung cancer
- Bladder cancer
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RELA |
RELA proto-oncogene, NF-kB subunit |
- Activation of NF-kappaB in B cells
- RIP-mediated NFkB activation via ZBP1
- Regulated proteolysis of p75NTR
- Downstream TCR signaling
- NF-kB is activated and signals survival
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated NF-kB activation
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- PKMTs methylate histone lysines
- Transcriptional regulation of white adipocyte differentiation
- TAK1-dependent IKK and NF-kappa-B activation
- Interleukin-1 processing
- SUMOylation of immune response proteins
- IkBA variant leads to EDA-ID
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- CD209 (DC-SIGN) signaling
- CLEC7A/inflammasome pathway
- The NLRP3 inflammasome
- Transcriptional Regulation by VENTX
- Interleukin-1 signaling
- TRAF6 mediated NF-kB activation
- Purinergic signaling in leishmaniasis infection
- SARS-CoV-1 activates/modulates innate immune responses
- Regulation of NFE2L2 gene expression
- Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
- Regulation of PD-L1(CD274) transcription
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- Glucosamine
- Dimethyl fumarate
- SC-236
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RPS6KB1 |
ribosomal protein S6 kinase B1 |
- mTORC1-mediated signalling
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RUVBL1 |
RuvB like AAA ATPase 1 |
- Telomere Extension By Telomerase
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- HATs acetylate histones
- UCH proteinases
- Ub-specific processing proteases
- DNA Damage Recognition in GG-NER
- Deposition of new CENPA-containing nucleosomes at the centromere
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RUVBL2 |
RuvB like AAA ATPase 2 |
- Telomere Extension By Telomerase
- HATs acetylate histones
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SERBP1 |
SERPINE1 mRNA binding protein 1 |
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SLC7A11 |
solute carrier family 7 member 11 |
- Basigin interactions
- Amino acid transport across the plasma membrane
- NFE2L2 regulating anti-oxidant/detoxification enzymes
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- Cystine
- Glutamic acid
- Riluzole
- Sulfasalazine
- Acetylcysteine
- Thimerosal
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SMG5 |
SMG5 nonsense mediated mRNA decay factor |
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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