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UBE2Q1 |
ubiquitin conjugating enzyme E2 Q1 |
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2V1 |
ubiquitin conjugating enzyme E2 V1 |
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- TAK1-dependent IKK and NF-kappa-B activation
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- PINK1-PRKN Mediated Mitophagy
- CLEC7A (Dectin-1) signaling
- Interleukin-1 signaling
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- Aggrephagy
- Aggrephagy
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2V2 |
ubiquitin conjugating enzyme E2 V2 |
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- G2/M DNA damage checkpoint
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2W |
ubiquitin conjugating enzyme E2 W |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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UNC45B |
unc-45 myosin chaperone B |
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VCP |
valosin containing protein |
- Translesion Synthesis by POLH
- HSF1 activation
- ABC-family proteins mediated transport
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Hedgehog ligand biogenesis
- Hh mutants are degraded by ERAD
- Defective CFTR causes cystic fibrosis
- Josephin domain DUBs
- Ovarian tumor domain proteases
- Neutrophil degranulation
- E3 ubiquitin ligases ubiquitinate target proteins
- Protein methylation
- Neddylation
- RHOH GTPase cycle
- Aggrephagy
- Attachment and Entry
- Attachment and Entry
- KEAP1-NFE2L2 pathway
- AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
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- Phosphoaminophosphonic Acid-Adenylate Ester
- Phenethyl Isothiocyanate
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- Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
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VDAC1 |
voltage dependent anion channel 1 |
- Mitochondrial protein import
- PINK1-PRKN Mediated Mitophagy
- Ub-specific processing proteases
- Pyruvate metabolism
- Mitochondrial calcium ion transport
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- Aluminium monostearate
- Cannabidiol
- Medical Cannabis
- Nabiximols
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XIAP |
X-linked inhibitor of apoptosis |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC, XIAP-regulated apoptotic response
- Deactivation of the beta-catenin transactivating complex
- RIPK1-mediated regulated necrosis
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NF-kappa-B signaling pathway
- Regulation of necroptotic cell death
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Regulation of the apoptosome activity
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- 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
- Dequalinium
- N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
- AEG35156
- Terpinen-4-ol
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- Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
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YTHDF2 |
YTH N6-methyladenosine RNA binding protein F2 |
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