PTEN - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ITPRID2	ITPR interacting domain containing 2
Novel	JUP	junction plakoglobin	Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CDH11 homotypic and heterotypic interactions	Zinc Zinc acetate	Naxos disease and Carvajal syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Novel	KBTBD4	kelch repeat and BTB domain containing 4
Novel	KDM1A	lysine demethylase 1A	HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production	Vafidemstat
Novel	KIF20B	kinesin family member 20B	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Novel	KPNB1	karyopherin subunit beta 1	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production SARS-CoV-1 activates/modulates innate immune responses Maturation of hRSV A proteins
Novel	LATS1	large tumor suppressor kinase 1	Signaling by Hippo	Fostamatinib
Novel	LGALS1	galectin 1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Mercaptoethanol Thiodigalactoside 1,4-Dithiothreitol Artenimol OTX-008
Novel	LIMA1	LIM domain and actin binding 1
Novel	LINC00839	long intergenic non-protein coding RNA 839
Novel	LINC01198	long intergenic non-protein coding RNA 1198
Novel	LINC02023	long intergenic non-protein coding RNA 2023
Novel	LIPF	lipase F, gastric type	Digestion of dietary lipid	Orlistat Undecyl-Phosphinic Acid Butyl Ester
Novel	LMNB1	lamin B1	Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerization of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle
Novel	LRPPRC	leucine rich pentatricopeptide repeat containing	Mitochondrial RNA degradation Mitochondrial mRNA modification
Novel	LTV1	LTV1 ribosome biogenesis factor	Major pathway of rRNA processing in the nucleolus and cytosol
Novel	MAGED2	MAGE family member D2	Platelet degranulation
Novel	MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	Nephrin family interactions
Novel	MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3
Novel	MAP2K3	mitogen-activated protein kinase kinase 3	Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation	Fostamatinib Pimasertib

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