APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ART4	ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)	Post-translational modification: synthesis of GPI-anchored proteins
ASB6	ankyrin repeat and SOCS box containing 6	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
ASCL3	achaete-scute family bHLH transcription factor 3
ASGR1	asialoglycoprotein receptor 1	Asparagine N-linked glycosylation	Von Willebrand factor human
ASH1L	ASH1 like histone lysine methyltransferase	PKMTs methylate histone lysines
ASMTL	acetylserotonin O-methyltransferase like
ASPH	aspartate beta-hydroxylase	Stimuli-sensing channels Ion homeostasis Protein hydroxylation	Aspartic acid
ASPSCR1	ASPSCR1 tether for SLC2A4, UBX domain containing	Translocation of SLC2A4 (GLUT4) to the plasma membrane		Alveolar soft part sarcoma
ASS1	argininosuccinate synthase 1	Urea cycle	Arginine Aspartic acid Aspartic acid Citrulline Citrulline ATP	Citrullinemia (CTLN)
ASXL1	ASXL transcriptional regulator 1	UCH proteinases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
ASXL2	ASXL transcriptional regulator 2	UCH proteinases
ATAT1	alpha tubulin acetyltransferase 1	Cargo trafficking to the periciliary membrane
ATCAY	ATCAY kinesin light chain interacting caytaxin			Cerebellar ataxia cayman type (ATCAY); Cayman ataxia
ATF2	activating transcription factor 2	Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2	Pseudoephedrine
ATF4	activating transcription factor 4	ATF4 activates genes in response to endoplasmic reticulum stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulating ER-stress associated genes	Pseudoephedrine
ATF6	activating transcription factor 6	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Modulation of host responses by IFN-stimulated genes	Pseudoephedrine
ATG12	autophagy related 12	Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
ATG13	autophagy related 13	Macroautophagy
ATG16L1	autophagy related 16 like 1	Macroautophagy		Crohn's disease
ATG7	autophagy related 7	Macroautophagy Macroautophagy Neutrophil degranulation Signaling by BRAF and RAF1 fusions Antigen processing: Ubiquitination & Proteasome degradation

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