Search Results for: APP

2116 interactions involving APP - amyloid beta precursor protein found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
RAB27A RAB27A, member RAS oncogene family
  • Insulin processing
  • Neutrophil degranulation
  • RAB geranylgeranylation
  • RAB GEFs exchange GTP for GDP on RABs
  • Regulation of MITF-M-dependent genes involved in pigmentation
  • Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
RAB28 RAB28, member RAS oncogene family
RAB2B RAB2B, member RAS oncogene family
  • RAB geranylgeranylation
RAB35 RAB35, member RAS oncogene family
  • TBC/RABGAPs
  • RAB geranylgeranylation
  • RAB GEFs exchange GTP for GDP on RABs
RAB38 RAB38, member RAS oncogene family
  • RAB geranylgeranylation
  • RAB GEFs exchange GTP for GDP on RABs
RAB39A RAB39A, member RAS oncogene family
  • Intra-Golgi traffic
  • RAB geranylgeranylation
  • RAB GEFs exchange GTP for GDP on RABs
RAB3A RAB3A, member RAS oncogene family
  • Serotonin Neurotransmitter Release Cycle
  • Norepinephrine Neurotransmitter Release Cycle
  • Glutamate Neurotransmitter Release Cycle
  • Dopamine Neurotransmitter Release Cycle
  • Acetylcholine Neurotransmitter Release Cycle
  • Neutrophil degranulation
  • RAB geranylgeranylation
  • RAB GEFs exchange GTP for GDP on RABs
  • GABA synthesis, release, reuptake and degradation
  • Sensory processing of sound by inner hair cells of the cochlea
RAB3D RAB3D, member RAS oncogene family
  • Neutrophil degranulation
  • RAB geranylgeranylation
RAB40B RAB40B, member RAS oncogene family
  • RAB geranylgeranylation
RAB43 RAB43, member RAS oncogene family
  • Retrograde transport at the Trans-Golgi-Network
  • RAB geranylgeranylation
RAB5C RAB5C, member RAS oncogene family
  • Golgi Associated Vesicle Biogenesis
  • Neutrophil degranulation
  • TBC/RABGAPs
  • Clathrin-mediated endocytosis
  • RAB geranylgeranylation
  • RAB GEFs exchange GTP for GDP on RABs
  • Respiratory syncytial virus (RSV) attachment and entry
RAB7B RAB7B, member RAS oncogene family
  • TBC/RABGAPs
  • RAB geranylgeranylation
  • RAB GEFs exchange GTP for GDP on RABs
RAB8B RAB8B, member RAS oncogene family
  • TBC/RABGAPs
  • RAB geranylgeranylation
  • RAB GEFs exchange GTP for GDP on RABs
  • Phosphoaminophosphonic acid guanylate ester
  • Guanosine-5'-Diphosphate
RABL3 RAB, member of RAS oncogene family like 3
RAD51AP1 RAD51 associated protein 1
  • HDR through Homologous Recombination (HRR)
  • Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
  • Resolution of D-loop Structures through Holliday Junction Intermediates
  • Homologous DNA Pairing and Strand Exchange
  • Defective homologous recombination repair (HRR) due to BRCA1 loss of function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
  • Impaired BRCA2 binding to PALB2
RAD51C RAD51 paralog C
  • HDR through Homologous Recombination (HRR)
  • Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
  • Resolution of D-loop Structures through Holliday Junction Intermediates
  • Homologous DNA Pairing and Strand Exchange
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Meiotic recombination
  • Defective homologous recombination repair (HRR) due to BRCA1 loss of function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
  • Impaired BRCA2 binding to PALB2
  • Factors involved in megakaryocyte development and platelet production
  • Fanconi anemia
RAG1 recombination activating 1
  • Interleukin-7 signaling
  • MAPK6/MAPK4 signaling
  • Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
  • T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
RAI2 retinoic acid induced 2
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RAP1B RAP1B, member of RAS oncogene family
  • Integrin signaling
  • GRB2:SOS provides linkage to MAPK signaling for Integrins
  • p130Cas linkage to MAPK signaling for integrins
  • Rap1 signalling
  • MAP2K and MAPK activation
  • Neutrophil degranulation
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by high-kinase activity BRAF mutants
  • Signaling by BRAF and RAF1 fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • MET activates RAP1 and RAC1
  • Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
  • Signaling downstream of RAS mutants
  • Signaling by RAF1 mutants

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