USP2 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
RABEP1	rabaptin, RAB GTPase binding effector protein 1	TBC/RABGAPs
RAD18	RAD18 E3 ubiquitin protein ligase	Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
RBCK1	RANBP2-type and C3HC4-type zinc finger containing 1	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
RFX6	regulatory factor X6	Regulation of gene expression in beta cells
RNF125	ring finger protein 125	Negative regulators of DDX58/IFIH1 signaling
RNF126	ring finger protein 126	Antigen processing: Ubiquitination & Proteasome degradation
RNF144B	ring finger protein 144B	Antigen processing: Ubiquitination & Proteasome degradation
RNF149	ring finger protein 149
RNF166	ring finger protein 166
RUNDC3A	RUN domain containing 3A
S100A10	S100 calcium binding protein A10	Dissolution of Fibrin Clot	Phenethyl Isothiocyanate
SH2B2	SH2B adaptor protein 2	Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
SLC2A1	solute carrier family 2 member 1	Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis	Resveratrol Carboxymethylcellulose	GLUT1 deficiency syndrome (GLUT1DS); Glucose transport defect of the blood-brain barrier Primary torsion dystonia (PTD)
SMAD7	SMAD family member 7	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases Interferon gamma signaling
SNCA	synuclein alpha	Amyloid fiber formation PKR-mediated signaling	Resveratrol Dequalinium Copper	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
SORBS3	sorbin and SH3 domain containing 3	Smooth Muscle Contraction
SPAG8	sperm associated antigen 8
SPDYE4	speedy/RINGO cell cycle regulator family member E4
STAT5B	signal transducer and activator of transcription 5B	Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Growth hormone receptor signaling	Dasatinib	Growth hormone insensitivity with immunodeficiency
TAX1BP1	Tax1 binding protein 1	Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling

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