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DHFR |
dihydrofolate reductase |
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Metabolism of folate and pterines
- G1/S-Specific Transcription
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- NADH
- Pyrimethamine
- Methotrexate
- Pemetrexed
- Gentamicin
- Proguanil
- Trimetrexate
- 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine
- 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]Quinazoline
- 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine
- N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine
- 2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine
- Sri-9662
- 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium
- Sri-9439
- Nicotinamide adenine dinucleotide phosphate
- Piritrexim
- Biopterin
- 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine
- Iclaprim
- Pralatrexate
- 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
- 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
- 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
- 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
- 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine
- [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE
- (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol
- (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
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DLEU1 |
deleted in lymphocytic leukemia 1 |
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DMTF1 |
cyclin D binding myb like transcription factor 1 |
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DNAJC7 |
DnaJ heat shock protein family (Hsp40) member C7 |
- Regulation of HSF1-mediated heat shock response
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DNMT3A |
DNA methyltransferase 3 alpha |
- PRC2 methylates histones and DNA
- RMTs methylate histone arginines
- SUMOylation of DNA methylation proteins
- DNA methylation
- Defective pyroptosis
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
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DNMT3L |
DNA methyltransferase 3 like |
- DNA methylation
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
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DTL |
denticleless E3 ubiquitin protein ligase adapter |
- Recognition of DNA damage by PCNA-containing replication complex
- Neddylation
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DVL2 |
dishevelled segment polarity protein 2 |
- TCF dependent signaling in response to WNT
- WNT mediated activation of DVL
- Signaling by Hippo
- PCP/CE pathway
- PCP/CE pathway
- Asymmetric localization of PCP proteins
- Degradation of DVL
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- WNT5A-dependent internalization of FZD4
- Negative regulation of TCF-dependent signaling by DVL-interacting proteins
- RHO GTPases Activate Formins
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- WNT5:FZD7-mediated leishmania damping
- WNT5:FZD7-mediated leishmania damping
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E2F1 |
E2F transcription factor 1 |
- Activation of NOXA and translocation to mitochondria
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
- Activation of PUMA and translocation to mitochondria
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- G2 Phase
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- G1/S-Specific Transcription
- Cyclin D associated events in G1
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional Regulation by E2F6
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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E4F1 |
E4F transcription factor 1 |
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EAF2 |
ELL associated factor 2 |
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Pre-transcription Events
- RNA Polymerase II Transcription Elongation
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EEF2 |
eukaryotic translation elongation factor 2 |
- Peptide chain elongation
- Peptide chain elongation
- Uptake and function of diphtheria toxin
- Synthesis of diphthamide-EEF2
- Synthesis of diphthamide-EEF2
- Neutrophil degranulation
- Protein methylation
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- Adenosine-5-Diphosphoribose
- Diphthamide
- Guanosine-5'-Diphosphate
- N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
- Esketamine
- Moxetumomab pasudotox
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EFEMP2 |
EGF-like fibulin extracellular matrix protein 2 |
- Molecules associated with elastic fibres
- Molecules associated with elastic fibres
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- Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
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EGLN3 |
egl-9 family hypoxia inducible factor 3 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
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- Ascorbic acid
- Roxadustat
- Daprodustat
- Vadadustat
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EGR1 |
early growth response 1 |
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- NGF-stimulated transcription
- NGF-stimulated transcription
- Interferon alpha/beta signaling
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EHMT1 |
euchromatic histone lysine methyltransferase 1 |
- Senescence-Associated Secretory Phenotype (SASP)
- PKMTs methylate histone lysines
- Regulation of TP53 Activity through Methylation
- Transcriptional Regulation by VENTX
- Transcriptional Regulation by E2F6
- Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
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- Kleefstra syndrome; 9q Subtelomeric deletion syndrome
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EHMT2 |
euchromatic histone lysine methyltransferase 2 |
- Senescence-Associated Secretory Phenotype (SASP)
- PKMTs methylate histone lysines
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- Regulation of TP53 Activity through Methylation
- RNA Polymerase I Transcription Initiation
- Transcriptional Regulation by VENTX
- Transcriptional Regulation by E2F6
- Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
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EIF2AK2 |
eukaryotic translation initiation factor 2 alpha kinase 2 |
- ISG15 antiviral mechanism
- Inhibition of PKR
- SUMOylation of immune response proteins
- Interferon alpha/beta signaling
- Evasion by RSV of host interferon responses
- PKR-mediated signaling
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- Indomethacin
- H-89
- Fostamatinib
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EIF2S2 |
eukaryotic translation initiation factor 2 subunit beta |
- L13a-mediated translational silencing of Ceruloplasmin expression
- PERK regulates gene expression
- PERK regulates gene expression
- ABC-family proteins mediated transport
- Translation initiation complex formation
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Recycling of eIF2:GDP
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Response of EIF2AK1 (HRI) to heme deficiency
- PKR-mediated signaling
- Cellular response to mitochondrial stress
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ELL |
elongation factor for RNA polymerase II |
- Formation of RNA Pol II elongation complex
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- Pausing and recovery of Tat-mediated HIV elongation
- Tat-mediated HIV elongation arrest and recovery
- Tat-mediated elongation of the HIV-1 transcript
- HIV elongation arrest and recovery
- Pausing and recovery of HIV elongation
- RNA Polymerase II Pre-transcription Events
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- TP53 Regulates Transcription of DNA Repair Genes
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- RNA Polymerase II Transcription Elongation
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