PTEN - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA SARS-CoV-1-host interactions SARS-CoV-1 modulates host translation machinery
Novel	HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Novel	HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B
Novel	HNRNPUL1	heterogeneous nuclear ribonucleoprotein U like 1
Novel	HSD17B1	hydroxysteroid 17-beta dehydrogenase 1	Estrogen biosynthesis The canonical retinoid cycle in rods (twilight vision)	NADH Androstenedione Androstanedione Equilin EM-1745 Stanolone Nicotinamide adenine dinucleotide phosphate Stanolone acetate
Novel	HSD17B10	hydroxysteroid 17-beta dehydrogenase 10	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion Mitochondrial protein degradation	NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids	Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH) 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
Novel	HSP90B1	heat shock protein 90 beta family member 1	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation	Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Novel	HSPA4	heat shock protein family A (Hsp70) member 4	Regulation of HSF1-mediated heat shock response	Phenethyl Isothiocyanate
Novel	HSPA4L	heat shock protein family A (Hsp70) member 4 like	Regulation of HSF1-mediated heat shock response
Novel	HSPA8	heat shock protein family A (Hsp70) member 8	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy Respiratory syncytial virus genome transcription PKR-mediated signaling	Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol
Novel	HSPBP1	HSPA (Hsp70) binding protein 1
Novel	HSPD1	heat shock protein family D (Hsp60) member 1	Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Copper	Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
Novel	HSPH1	heat shock protein family H (Hsp110) member 1	Scavenging by Class F Receptors Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response	Phenethyl Isothiocyanate
Novel	IL24	interleukin 24	Interleukin-20 family signaling
Novel	ILF2	interleukin enhancer binding factor 2	Neutrophil degranulation PKR-mediated signaling
Novel	ILF3	interleukin enhancer binding factor 3	Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription PKR-mediated signaling
Novel	INS	insulin	Regulation of gene expression in beta cells Insulin processing Insulin processing Synthesis, secretion, and deacylation of Ghrelin Regulation of insulin secretion COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NPAS4 regulates expression of target genes Amyloid fiber formation	Glisoxepide Zinc M-Cresol Myristic acid Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Permanent neonatal diabetes mellitus (PNDM) Type I diabetes mellitus Maturity onset diabetes of the young (MODY)
Novel	IPO5	importin 5	vRNP Assembly
Novel	IPO7	importin 7
Novel	IRS4	insulin receptor substrate 4	IRS-related events triggered by IGF1R

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