OGT - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CXADR	CXADR cell adhesion molecule	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall
DAPK3	death associated protein kinase 3	Caspase activation via Dependence Receptors in the absence of ligand	2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Fostamatinib
DAZAP1	DAZ associated protein 1
DBN1	drebrin 1	RHOD GTPase cycle RHOH GTPase cycle RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
DBNL	drebrin like	Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation
DBT	dihydrolipoamide branched chain transacylase E2	Branched-chain amino acid catabolism RHOH GTPase cycle Mitochondrial protein degradation Protein lipoylation BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV Loss-of-function mutations in DBT cause MSUD2 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD Loss-of-function mutations in DLD cause MSUD3/DLDD Branched-chain ketoacid dehydrogenase kinase deficiency H139Hfs13* PPM1K causes a mild variant of MSUD		Maple syrup urine disease (MSUD)
DCTN2	dynactin subunit 2	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
DDX17	DEAD-box helicase 17	SUMOylation of transcription cofactors
DDX28	DEAD-box helicase 28
DDX39B	DExD-box helicase 39B	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination RHOBTB2 GTPase cycle	Artenimol
DDX3X	DEAD-box helicase 3 X-linked	Neutrophil degranulation
DDX41	DEAD-box helicase 41	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN mRNA Splicing - Major Pathway
DDX47	DEAD-box helicase 47	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
DDX5	DEAD-box helicase 5	SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome	Artenimol	Prostate cancer
DDX56	DEAD-box helicase 56
DEK	DEK proto-oncogene	B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
DHX30	DExH-box helicase 30
DHX9	DExH-box helicase 9	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway PKR-mediated signaling
DLD	dihydrolipoamide dehydrogenase	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Glycine degradation Branched-chain amino acid catabolism Mitochondrial protein degradation OGDH complex synthesizes succinyl-CoA from 2-OG OADH complex synthesizes glutaryl-CoA from 2-OA BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV PDH complex synthesizes acetyl-CoA from PYR Loss-of-function mutations in DBT cause MSUD2 Loss-of-function mutations in DLD cause MSUD3/DLDD Branched-chain ketoacid dehydrogenase kinase deficiency H139Hfs13* PPM1K causes a mild variant of MSUD	NADH Flavin adenine dinucleotide	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome Maple syrup urine disease (MSUD)
DLG3	discs large MAGUK scaffold protein 3	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation		Non-syndromic X-linked mental retardation

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