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HSP90AB1 |
heat shock protein 90 alpha family class B member 1 |
- DDX58/IFIH1-mediated induction of interferon-alpha/beta
- Regulation of actin dynamics for phagocytic cup formation
- HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
- HSF1 activation
- Attenuation phase
- HSF1-dependent transactivation
- Sema3A PAK dependent Axon repulsion
- Uptake and function of diphtheria toxin
- Neutrophil degranulation
- The NLRP3 inflammasome
- The role of GTSE1 in G2/M progression after G2 checkpoint
- Aryl hydrocarbon receptor signalling
- ESR-mediated signaling
- RHOBTB2 GTPase cycle
- Estrogen-dependent gene expression
- Chaperone Mediated Autophagy
- Purinergic signaling in leishmaniasis infection
- Potential therapeutics for SARS
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
- Assembly and release of respiratory syncytial virus (RSV) virions
- Respiratory syncytial virus genome replication
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- Geldanamycin
- 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
- Radicicol
- Tanespimycin
- SNX-5422
- CCT-018159
- 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
- 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL
- (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE
- (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
- (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
- (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE
- METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE
- 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
- Polaprezinc
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HSP90B1 |
heat shock protein 90 beta family member 1 |
- Trafficking and processing of endosomal TLR
- Scavenging by Class A Receptors
- Scavenging by Class A Receptors
- ATF6 (ATF6-alpha) activates chaperone genes
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Interleukin-4 and Interleukin-13 signaling
- Post-translational protein phosphorylation
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- Rifabutin
- 2-Chlorodideoxyadenosine
- Geldanamycin
- Diglyme
- N-Ethyl-5'-Carboxamido Adenosine
- Radicicol
- METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE
- 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
- Copper
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HSPA4 |
heat shock protein family A (Hsp70) member 4 |
- Regulation of HSF1-mediated heat shock response
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HSPA8 |
heat shock protein family A (Hsp70) member 8 |
- Regulation of HSF1-mediated heat shock response
- HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
- Attenuation phase
- HSF1-dependent transactivation
- Lysosome Vesicle Biogenesis
- Golgi Associated Vesicle Biogenesis
- CHL1 interactions
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Interleukin-4 and Interleukin-13 signaling
- Neutrophil degranulation
- mRNA Splicing - Major Pathway
- Clathrin-mediated endocytosis
- Protein methylation
- GABA synthesis, release, reuptake and degradation
- Lipophagy
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Respiratory syncytial virus genome transcription
- PKR-mediated signaling
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- Dasatinib
- (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
- Copper
- Artenimol
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HSPB1 |
heat shock protein family B (small) member 1 |
- VEGFA-VEGFR2 Pathway
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- MAPK6/MAPK4 signaling
- Extra-nuclear estrogen signaling
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- Apatorsen
- Artenimol
- Phenethyl Isothiocyanate
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- Distal hereditary motor neuropathies (dHMN)
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IGF1R |
insulin like growth factor 1 receptor |
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- IRS-related events triggered by IGF1R
- SHC-related events triggered by IGF1R
- Extra-nuclear estrogen signaling
- Respiratory syncytial virus (RSV) attachment and entry
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- Insulin human
- Insulin lispro
- Insulin glargine
- Insulin pork
- Mecasermin
- Insulin aspart
- Insulin detemir
- Insulin glulisine
- Phosphoaminophosphonic Acid-Adenylate Ester
- ATL1101
- XL228
- rhIGFBP-3
- Linsitinib
- Teprotumumab
- (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione
- 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
- Nandrolone decanoate
- Somatrem
- Insulin beef
- Insulin degludec
- Insulin argine
- Insulin peglispro
- Insulin tregopil
- Dalotuzumab
- Cixutumumab
- Brigatinib
- Mecasermin rinfabate
- BMS-754807
- KW-2450 free base
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- Synovial sarcoma
- Malignant pleural mesothelioma
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ILF3 |
interleukin enhancer binding factor 3 |
- Regulation of CDH11 gene transcription
- Regulation of CDH11 gene transcription
- PKR-mediated signaling
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ING1 |
inhibitor of growth family member 1 |
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ISL1 |
ISL LIM homeobox 1 |
- Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
- Regulation of expression of SLITs and ROBOs
- Cardiogenesis
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ITGB3BP |
integrin subunit beta 3 binding protein |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- NRIF signals cell death from the nucleus
- NRIF signals cell death from the nucleus
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Deposition of new CENPA-containing nucleosomes at the centromere
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated MAPK activation
- Activation of the AP-1 family of transcription factors
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- MAPK6/MAPK4 signaling
- TP53 Regulates Transcription of DNA Repair Genes
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Estrogen-dependent gene expression
- WNT5:FZD7-mediated leishmania damping
- Signaling by ALK fusions and activated point mutants
- Regulation of PD-L1(CD274) transcription
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- Adapalene
- Vinblastine
- Pseudoephedrine
- Irbesartan
- Arsenic trioxide
- LGD-1550
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JUNB |
JunB proto-oncogene, AP-1 transcription factor subunit |
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Interleukin-4 and Interleukin-13 signaling
- NGF-stimulated transcription
- NGF-stimulated transcription
- Nuclear events stimulated by ALK signaling in cancer
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JUND |
JunD proto-oncogene, AP-1 transcription factor subunit |
- Estrogen-dependent gene expression
- NGF-stimulated transcription
- NGF-stimulated transcription
- Regulation of PD-L1(CD274) transcription
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KARS1 |
lysyl-tRNA synthetase 1 |
- Selenoamino acid metabolism
- Cytosolic tRNA aminoacylation
- Mitochondrial tRNA aminoacylation
- Transcriptional and post-translational regulation of MITF-M expression and activity
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- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
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KAT5 |
lysine acetyltransferase 5 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- DNA Damage/Telomere Stress Induced Senescence
- HATs acetylate histones
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Estrogen-dependent gene expression
- Defective homologous recombination repair (HRR) due to BRCA1 loss of function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
- Impaired BRCA2 binding to RAD51
- Impaired BRCA2 binding to PALB2
- Cardiogenesis
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- Coenzyme A
- S-Acetyl-Cysteine
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KDM5A |
lysine demethylase 5A |
- HDMs demethylate histones
- Chromatin modifications during the maternal to zygotic transition (MZT)
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KIF1A |
kinesin family member 1A |
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
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- Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
- Phosphoaminophosphonic Acid-Adenylate Ester
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KLF5 |
KLF transcription factor 5 |
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of granulopoiesis
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KLK5 |
kallikrein related peptidase 5 |
- Formation of the cornified envelope
- Formation of the cornified envelope
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
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KLK9 |
kallikrein related peptidase 9 |
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