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GNAS |
GNAS complex locus |
- Glucagon signaling in metabolic regulation
- PKA activation in glucagon signalling
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Prostacyclin signalling through prostacyclin receptor
- Prostacyclin signalling through prostacyclin receptor
- G alpha (s) signalling events
- G alpha (s) signalling events
- G alpha (i) signalling events
- G alpha (z) signalling events
- Glucagon-type ligand receptors
- Vasopressin regulates renal water homeostasis via Aquaporins
- Hedgehog 'off' state
- GPER1 signaling
- GPER1 signaling
- ADORA2B mediated anti-inflammatory cytokines production
- ADORA2B mediated anti-inflammatory cytokines production
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
- Glucagon signaling in metabolic regulation
- PKA activation in glucagon signalling
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Prostacyclin signalling through prostacyclin receptor
- Prostacyclin signalling through prostacyclin receptor
- G alpha (s) signalling events
- G alpha (s) signalling events
- G alpha (i) signalling events
- G alpha (z) signalling events
- Glucagon-type ligand receptors
- Vasopressin regulates renal water homeostasis via Aquaporins
- Hedgehog 'off' state
- GPER1 signaling
- GPER1 signaling
- ADORA2B mediated anti-inflammatory cytokines production
- ADORA2B mediated anti-inflammatory cytokines production
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
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- Colforsin
- 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
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- Pseudohypoparathyroidism
- Progressive osseous heteroplasia (POH)
- Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy
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GRK3 |
G protein-coupled receptor kinase 3 |
- G alpha (s) signalling events
- Cargo recognition for clathrin-mediated endocytosis
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HMGN1 |
high mobility group nucleosome binding domain 1 |
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HOXC6 |
homeobox C6 |
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ITIH5 |
inter-alpha-trypsin inhibitor heavy chain 5 |
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KLK7 |
kallikrein related peptidase 7 |
- Degradation of the extracellular matrix
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
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- L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
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KLK9 |
kallikrein related peptidase 9 |
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KPNA2 |
karyopherin subunit alpha 2 |
- CaMK IV-mediated phosphorylation of CREB
- ISG15 antiviral mechanism
- NS1 Mediated Effects on Host Pathways
- CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
- Sensing of DNA Double Strand Breaks
- Estrogen-dependent gene expression
- SARS-CoV-1 activates/modulates innate immune responses
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
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LATS2 |
large tumor suppressor kinase 2 |
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LYPD3 |
LY6/PLAUR domain containing 3 |
- Post-translational modification: synthesis of GPI-anchored proteins
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MAPT |
microtubule associated protein tau |
- Caspase-mediated cleavage of cytoskeletal proteins
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- Lansoprazole
- Astemizole
- Paclitaxel
- Docetaxel
- Flortaucipir F-18
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- Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome
- Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
- Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
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MDC1 |
mediator of DNA damage checkpoint 1 |
- SUMOylation of DNA damage response and repair proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- TP53 Regulates Transcription of DNA Repair Genes
- G2/M DNA damage checkpoint
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MDM2 |
MDM2 proto-oncogene |
- AKT phosphorylates targets in the cytosol
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- Trafficking of AMPA receptors
- Constitutive Signaling by AKT1 E17K in Cancer
- Ub-specific processing proteases
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- Stabilization of p53
- Regulation of RUNX3 expression and activity
- Signaling by ALK fusions and activated point mutants
- Degradation of CDH1
- NPAS4 regulates expression of target genes
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- Zinc
- Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
- Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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- Penile cancer
- Alveolar rhabdomyosarcoma
- Choriocarcinoma
- Osteosarcoma
- Glioma
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MDM4 |
MDM4 regulator of p53 |
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- Ub-specific processing proteases
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- Stabilization of p53
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MED1 |
mediator complex subunit 1 |
- BMAL1:CLOCK,NPAS2 activates circadian expression
- PPARA activates gene expression
- PPARA activates gene expression
- Generic Transcription Pathway
- Transcriptional activation of mitochondrial biogenesis
- Activation of gene expression by SREBF (SREBP)
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by PPARalpha
- Estrogen-dependent gene expression
- Cytoprotection by HMOX1
- Heme signaling
- RSV-host interactions
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
- Expression of BMAL (ARNTL), CLOCK, and NPAS2
- RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
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MN1 |
MN1 proto-oncogene, transcriptional regulator |
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MRC1 |
mannose receptor C-type 1 |
- Cross-presentation of soluble exogenous antigens (endosomes)
- Cross-presentation of soluble exogenous antigens (endosomes)
- Modulation by Mtb of host immune system
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- Technetium Tc-99m tilmanocept
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MSH2 |
mutS homolog 2 |
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Defective Mismatch Repair Associated With MSH3
- Defective Mismatch Repair Associated With MSH2
- Defective Mismatch Repair Associated With MSH6
- TP53 Regulates Transcription of DNA Repair Genes
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- Ovarian cancer
- Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
- Colorectal cancer
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MUS81 |
MUS81 structure-specific endonuclease subunit |
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Fanconi Anemia Pathway
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NBN |
nibrin |
- DNA Damage/Telomere Stress Induced Senescence
- HDR through Single Strand Annealing (SSA)
- HDR through MMEJ (alt-NHEJ)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Meiotic recombination
- Defective homologous recombination repair (HRR) due to BRCA1 loss of function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
- Impaired BRCA2 binding to RAD51
- Impaired BRCA2 binding to PALB2
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- DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
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