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Novel |
RASSF1 |
Ras association domain family member 1 |
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- Nasopharyngeal cancer
- Non-small cell lung cancer
- Bladder cancer
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Novel |
RBM26 |
RNA binding motif protein 26 |
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Novel |
RIN2 |
Ras and Rab interactor 2 |
- RAB GEFs exchange GTP for GDP on RABs
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- Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome
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Novel |
RPL11 |
ribosomal protein L11 |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Peptide chain elongation
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- Viral mRNA Translation
- Selenocysteine synthesis
- Major pathway of rRNA processing in the nucleolus and cytosol
- Formation of a pool of free 40S subunits
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Termination
- Regulation of expression of SLITs and ROBOs
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
- ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
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- (S)-3-phenyllactic acid
- Anisomycin
- Puromycin
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- Diamond-Blackfan anemia (DBA)
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Novel |
RPS7 |
ribosomal protein S7 |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Peptide chain elongation
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- Viral mRNA Translation
- Selenocysteine synthesis
- rRNA modification in the nucleus and cytosol
- Major pathway of rRNA processing in the nucleolus and cytosol
- Translation initiation complex formation
- Formation of a pool of free 40S subunits
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Termination
- Regulation of expression of SLITs and ROBOs
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- SARS-CoV-1 modulates host translation machinery
- SARS-CoV-2 modulates host translation machinery
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
- ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
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- Diamond-Blackfan anemia (DBA)
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Novel |
RUVBL2 |
RuvB like AAA ATPase 2 |
- Telomere Extension By Telomerase
- HATs acetylate histones
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Novel |
SEC61B |
SEC61 translocon subunit beta |
- ER-Phagosome pathway
- SRP-dependent cotranslational protein targeting to membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
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Novel |
SERTAD1 |
SERTA domain containing 1 |
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Novel |
SFRP4 |
secreted frizzled related protein 4 |
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- Cyclothiazide
- Perindopril
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Novel |
SGK1 |
serum/glucocorticoid regulated kinase 1 |
- PIP3 activates AKT signaling
- Stimuli-sensing channels
- Regulation of TP53 Degradation
- Transcriptional Regulation by MECP2
- NGF-stimulated transcription
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- Flavin mononucleotide
- [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid
- 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
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Novel |
SIT1 |
signaling threshold regulating transmembrane adaptor 1 |
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Novel |
SIVA1 |
SIVA1 apoptosis inducing factor |
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- Zinc
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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Novel |
SIX2 |
SIX homeobox 2 |
- Formation of the ureteric bud
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Novel |
SLC4A1 |
solute carrier family 4 member 1 (Diego blood group) |
- Erythrocytes take up carbon dioxide and release oxygen
- Erythrocytes take up oxygen and release carbon dioxide
- Bicarbonate transporters
- Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
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- Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
- Distal renal tubular acidosis (RTA type 1)
- Hereditary spherocytosis (SPH)
- Hereditary elliptocytosis (HE)
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Novel |
SMARCA4 |
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 |
- Interleukin-7 signaling
- Formation of the beta-catenin:TCF transactivating complex
- RMTs methylate histone arginines
- Chromatin modifying enzymes
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- Negative Regulation of CDH1 Gene Transcription
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
- Formation of the canonical BAF (cBAF) complex
- Formation of the polybromo-BAF (pBAF) complex
- Formation of the embryonic stem cell BAF (esBAF) complex
- Formation of the non-canonical BAF (ncBAF) complex
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
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Novel |
SNRPA |
small nuclear ribonucleoprotein polypeptide A |
- mRNA Splicing - Major Pathway
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Novel |
SNRPB |
small nuclear ribonucleoprotein polypeptides B and B1 |
- SLBP independent Processing of Histone Pre-mRNAs
- snRNP Assembly
- mRNA Splicing - Major Pathway
- mRNA Splicing - Minor Pathway
- RNA Polymerase II Transcription Termination
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
- SARS-CoV-2 modulates host translation machinery
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Novel |
SOX3 |
SRY-box transcription factor 3 |
- Deactivation of the beta-catenin transactivating complex
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- Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
- Septo-optic dysplasia
- 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
- Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
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Novel |
SOX4 |
SRY-box transcription factor 4 |
- Deactivation of the beta-catenin transactivating complex
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Novel |
STK11 |
serine/threonine kinase 11 |
- AMPK inhibits chREBP transcriptional activation activity
- Energy dependent regulation of mTOR by LKB1-AMPK
- Regulation of TP53 Activity through Phosphorylation
- FOXO-mediated transcription of cell death genes
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- Peutz-Jeghers syndrome
- Pancreatic cancer
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