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PLK1 |
polo like kinase 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Polo-like kinase mediated events
- Golgi Cisternae Pericentriolar Stack Reorganization
- Golgi Cisternae Pericentriolar Stack Reorganization
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Phosphorylation of the APC/C
- Phosphorylation of Emi1
- Condensation of Prophase Chromosomes
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- Activation of NIMA Kinases NEK9, NEK6, NEK7
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- Mitotic Metaphase/Anaphase Transition
- Mitotic Telophase/Cytokinesis
- Cyclin A/B1/B2 associated events during G2/M transition
- The role of GTSE1 in G2/M progression after G2 checkpoint
- AURKA Activation by TPX2
- EML4 and NUDC in mitotic spindle formation
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
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- 3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
- 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
- 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
- 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
- Wortmannin
- Fostamatinib
- Volasertib
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PLK2 |
polo like kinase 2 |
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- CD163 mediating an anti-inflammatory response
- NPAS4 regulates expression of target genes
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PLPP3 |
phospholipid phosphatase 3 |
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PLRG1 |
pleiotropic regulator 1 |
- mRNA Splicing - Major Pathway
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PLS3 |
plastin 3 |
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PLSCR1 |
phospholipid scramblase 1 |
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PNKD |
PNKD metallo-beta-lactamase domain containing |
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- Primary torsion dystonia (PTD)
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PNKP |
polynucleotide kinase 3'-phosphatase |
- APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
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- Early infantile epileptic encephalopathy; Ohtahara syndrome
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PNMA8A |
PNMA family member 8A |
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PNPO |
pyridoxamine 5'-phosphate oxidase |
- Vitamin B6 activation to pyridoxal phosphate
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- Pyridoxal phosphate
- Flavin mononucleotide
- Mercaptoethanol
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PNRC2 |
proline rich nuclear receptor coactivator 2 |
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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POGK |
pogo transposable element derived with KRAB domain |
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POGZ |
pogo transposable element derived with ZNF domain |
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POLA2 |
DNA polymerase alpha 2, accessory subunit |
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Polymerase switching on the C-strand of the telomere
- Telomere C-strand synthesis initiation
- DNA replication initiation
- Activation of the pre-replicative complex
- Polymerase switching
- Removal of the Flap Intermediate
- Processive synthesis on the lagging strand
- Defective pyroptosis
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POLD3 |
DNA polymerase delta 3, accessory subunit |
- Recognition of DNA damage by PCNA-containing replication complex
- Polymerase switching on the C-strand of the telomere
- Processive synthesis on the C-strand of the telomere
- Telomere C-strand (Lagging Strand) Synthesis
- Removal of the Flap Intermediate from the C-strand
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- PCNA-Dependent Long Patch Base Excision Repair
- Termination of translesion DNA synthesis
- HDR through Homologous Recombination (HRR)
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Polymerase switching
- Removal of the Flap Intermediate
- Processive synthesis on the lagging strand
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POLDIP2 |
DNA polymerase delta interacting protein 2 |
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POLE3 |
DNA polymerase epsilon 3, accessory subunit |
- Recognition of DNA damage by PCNA-containing replication complex
- PCNA-Dependent Long Patch Base Excision Repair
- Termination of translesion DNA synthesis
- HDR through Homologous Recombination (HRR)
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- DNA replication initiation
- Activation of the pre-replicative complex
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POLH |
DNA polymerase eta |
- Translesion Synthesis by POLH
- Termination of translesion DNA synthesis
- HDR through Homologous Recombination (HRR)
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- Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
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POLI |
DNA polymerase iota |
- Translesion synthesis by POLI
- Termination of translesion DNA synthesis
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POLL |
DNA polymerase lambda |
- Nonhomologous End-Joining (NHEJ)
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