APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
PGM3	phosphoglucomutase 3	Synthesis of UDP-N-acetyl-glucosamine
PHACTR4	phosphatase and actin regulator 4
PHAF1	phagophore assembly factor 1
PHF20L1	PHD finger protein 20 like 1	Formation of WDR5-containing histone-modifying complexes
PHF7	PHD finger protein 7
PHF8	PHD finger protein 8	HDMs demethylate histones		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
PHGDH	phosphoglycerate dehydrogenase	Serine metabolism	NADH
PHLDA1	pleckstrin homology like domain family A member 1	Interaction between PHLDA1 and AURKA MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
PHLDA3	pleckstrin homology like domain family A member 3
PHYH	phytanoyl-CoA 2-hydroxylase	Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Antihemophilic factor, human recombinant Ascorbic acid Lonoctocog alfa Moroctocog alfa	Refsum disease; Heredopathia atactica polyneuritiformis
PHYHD1	phytanoyl-CoA dioxygenase domain containing 1
PI4K2A	phosphatidylinositol 4-kinase type 2 alpha	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane
PIBF1	progesterone immunomodulatory binding factor 1
PIGG	phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)	Synthesis of glycosylphosphatidylinositol (GPI)
PIGO	phosphatidylinositol glycan anchor biosynthesis class O	Synthesis of glycosylphosphatidylinositol (GPI)
PIK3R2	phosphoinositide-3-kinase regulatory subunit 2	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS	SF1126
PIK3R5	phosphoinositide-3-kinase regulatory subunit 5	GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Co-stimulation by ICOS
PIKFYVE	phosphoinositide kinase, FYVE-type zinc finger containing	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane		Fleck corneal dystrophy (FCD); Francois-Neetens speckled corneal dystrophy
PIM1	Pim-1 proto-oncogene, serine/threonine kinase	Interleukin-4 and Interleukin-13 signaling STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins	3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Staurosporine LY-294002 Imidazole (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Bisindolylmaleimide I Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine S,S-(2-Hydroxyethyl)Thiocysteine IMIDAZOPYRIDAZIN 1 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Tricetin 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine 2,3-diphenyl-1H-indole-7-carboxylic acid Fostamatinib
PIMREG	PICALM interacting mitotic regulator

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