APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
PDCD7	programmed cell death 7	mRNA Splicing - Minor Pathway
PDE1A	phosphodiesterase 1A	Cam-PDE 1 activation cGMP effects G alpha (s) signalling events	Caffeine Nicardipine Felodipine Bepridil Trapidil
PDE4D	phosphodiesterase 4D	DARPP-32 events G alpha (s) signalling events	Adenosine phosphate Caffeine Caffeine Dyphylline Iloprost Papaverine Amrinone Roflumilast Piclamilast Rolipram Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol Zardaverine 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Exisulind (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
PDE6H	phosphodiesterase 6H		Sildenafil Vardenafil	Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
PDIA3	protein disulfide isomerase family A member 3	ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
PDK3	pyruvate dehydrogenase kinase 3	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid	Radicicol Dihydrolipoic Acid
PDPK1	3-phosphoinositide dependent protein kinase 1	GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Activation of AKT2 Downstream TCR signaling Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated NF-kB activation Integrin signaling CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma RSK activation VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases activate PKNs Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine Bisindolylmaleimide VIII Staurosporine Bisindolylmaleimide I Dexfosfoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE Fostamatinib
PDS5B	PDS5 cohesin associated factor B	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
PDSS2	decaprenyl diphosphate synthase subunit 2	Ubiquinol biosynthesis		Coenzyme Q10 deficiency
PDYN	prodynorphin	Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
PDZD4	PDZ domain containing 4
PDZD9	PDZ domain containing 9
PDZK1	PDZ domain containing 1
PEG3	paternally expressed 3
PELI3	pellino E3 ubiquitin protein ligase family member 3	Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
PES1	pescadillo ribosomal biogenesis factor 1	Major pathway of rRNA processing in the nucleolus and cytosol
PEX2	peroxisomal biogenesis factor 2	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
PFKL	phosphofructokinase, liver type	Neutrophil degranulation Glycolysis
PGM1	phosphoglucomutase 1	Glycogen synthesis Defective PGM1 causes PGM1-CDG Neutrophil degranulation Glycogen breakdown (glycogenolysis) Galactose catabolism	Alpha-D-Glucose 1,6-Bisphosphate Alpha-D-Glucose-1-Phosphate-6-Vanadate

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