Search Results for: APP

2116 interactions involving APP - amyloid beta precursor protein found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
PARVG parvin gamma
PASD1 PAS domain containing repressor 1
PATL1 PAT1 homolog 1, processing body mRNA decay factor
  • mRNA decay by 5' to 3' exoribonuclease
  • mRNA decay by 5' to 3' exoribonuclease
PAX6 paired box 6
  • Regulation of gene expression in beta cells
  • Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
  • Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Formation of the anterior neural plate
  • Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON)
  • Aniridia
  • Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
PAXIP1 PAX interacting protein 1
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Nonhomologous End-Joining (NHEJ)
  • Formation of WDR5-containing histone-modifying complexes
  • Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
  • MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
PAXX PAXX non-homologous end joining factor
PBRM1 polybromo 1
  • RMTs methylate histone arginines
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • Formation of the polybromo-BAF (pBAF) complex
PCBD1 pterin-4 alpha-carbinolamine dehydratase 1
  • Phenylalanine metabolism
  • L-erythro-7,8-dihydrobiopterin
  • Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
PCBD2 pterin-4 alpha-carbinolamine dehydratase 2
PCBP1 poly(rC) binding protein 1
  • mRNA Splicing - Major Pathway
  • Processing of Capped Intron-Containing Pre-mRNA
PCDHA7 protocadherin alpha 7
PCDHGA12 protocadherin gamma subfamily A, 12
PCDHGC3 protocadherin gamma subfamily C, 3
PCDHGC5 protocadherin gamma subfamily C, 5
PCIF1 phosphorylated CTD interacting factor 1
PCK1 phosphoenolpyruvate carboxykinase 1
  • Abacavir metabolism
  • Transcriptional regulation of white adipocyte differentiation
  • Gluconeogenesis
  • FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
  • NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
  • Phosphoenolpyruvate
  • 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine
  • 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine
  • 5'-Guanylylmethylenebisphosphonate
PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial
  • Gluconeogenesis
PCM1 pericentriolar material 1
  • Regulation of PLK1 Activity at G2/M Transition
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Anchoring of the basal body to the plasma membrane
  • AURKA Activation by TPX2
PCYT1B phosphate cytidylyltransferase 1B, choline
  • Synthesis of PC
  • Choline
  • Choline salicylate
PDAP1 PDGFA associated protein 1
  • Neutrophil degranulation

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