WT1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HMBOX1	homeobox containing 1
IDI1	isopentenyl-diphosphate delta isomerase 1	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Dimethylallyl Diphosphate
IPO8	importin 8	Transcriptional regulation by small RNAs
KLK7	kallikrein related peptidase 7	Degradation of the extracellular matrix Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
KPNA4	karyopherin subunit alpha 4	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
KPNA5	karyopherin subunit alpha 5	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
KRT40	keratin 40	Keratinization Formation of the cornified envelope
KRTAP10-1	keratin associated protein 10-1	Keratinization
KRTAP10-3	keratin associated protein 10-3	Keratinization
KRTAP10-4	keratin associated protein 10-4	Keratinization
KRTAP10-5	keratin associated protein 10-5	Keratinization
KRTAP10-6	keratin associated protein 10-6	Keratinization
KRTAP10-7	keratin associated protein 10-7	Keratinization
KRTAP10-8	keratin associated protein 10-8	Keratinization
KRTAP10-9	keratin associated protein 10-9	Keratinization
LDOC1	LDOC1 regulator of NFKB signaling
MAGEA8	MAGE family member A8
MDM2	MDM2 proto-oncogene	AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity Signaling by ALK fusions and activated point mutants Degradation of CDH1 NPAS4 regulates expression of target genes	Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Penile cancer Alveolar rhabdomyosarcoma Choriocarcinoma Osteosarcoma Glioma
MYC	MYC proto-oncogene, bHLH transcription factor	Transcription of E2F targets under negative control by DREAM complex Signaling by ALK NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Binding of TCF/LEF:CTNNB1 to target gene promoters MAPK6/MAPK4 signaling Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry TFAP2 (AP-2) family regulates transcription of cell cycle factors RUNX3 regulates WNT signaling Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Regulation of CDH1 mRNA translation by microRNAs Regulation of NFE2L2 gene expression Regulation of PD-L1(CD274) transcription	Acetylsalicylic acid Dimethyl sulfoxide Doconexent Nadroparin	Penile cancer Breast cancer Laryngeal cancer Oral cancer Multiple myeloma Kaposi's sarcoma Ovarian cancer Choriocarcinoma Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Burkitt lymphoma Small cell lung cancer Osteosarcoma Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
NAT2	N-acetyltransferase 2	Acetylation Paracetamol ADME

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