KEAP1 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	USP15	ubiquitin specific peptidase 15	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Novel	VAC14	VAC14 component of PIKFYVE complex	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Novel	WDR83	WD repeat domain 83	MAP2K and MAPK activation
Novel	WHRN	whirlin	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea		Deafness, autosomal recessive Usher syndrome (US)
Novel	ZNF121	zinc finger protein 121
Novel	ZNF177	zinc finger protein 177
Novel	ZNF266	zinc finger protein 266	Generic Transcription Pathway
Novel	ZSCAN32	zinc finger and SCAN domain containing 32	Generic Transcription Pathway
	ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	Ethanol oxidation	NADH Lauric acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
	AK4	adenylate kinase 4	Interconversion of nucleotide di- and triphosphates
	AMER1	APC membrane recruitment protein 1	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Neddylation KEAP1-NFE2L2 pathway		Osteopathia striata with cranial sclerosis
	ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A
	ARPC1B	actin related protein 2/3 complex subunit 1B	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
	ASTN1	astrotactin 1
	ATF5	activating transcription factor 5	Response of EIF2AK1 (HRI) to heme deficiency Mitochondrial unfolded protein response (UPRmt) Mitochondrial unfolded protein response (UPRmt)	Pseudoephedrine
	ATG5	autophagy related 5	Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
	BAD	BCL2 associated agonist of cell death	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer	Navitoclax
	BNIP3L	BCL2 interacting protein 3 like	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
	BPTF	bromodomain PHD finger transcription factor
	BTRC	beta-transducin repeat containing E3 ubiquitin protein ligase	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Neddylation Interleukin-1 signaling GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins

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