HRAS - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
PTPRJ	protein tyrosine phosphatase receptor type J	Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3
QPCT	glutaminyl-peptide cyclotransferase	Neutrophil degranulation	1-benzylimidazole N-acetylhistamine Glutamine t-butyl ester
RAB5C	RAB5C, member RAS oncogene family	Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry
RABAC1	Rab acceptor 1
RABGEF1	RAB guanine nucleotide exchange factor 1	TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
RAF1	Raf-1 proto-oncogene, serine/threonine kinase	Stimuli-sensing channels Rap1 signalling GP1b-IX-V activation signalling CD209 (DC-SIGN) signaling RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling IFNG signaling activates MAPKs	Sorafenib LErafAON XL281 iCo-007 Cholecystokinin Regorafenib Dabrafenib Fostamatinib
RALGDS	ral guanine nucleotide dissociation stimulator	p38MAPK events p38MAPK events RAF/MAP kinase cascade
RAP1B	RAP1B, member of RAS oncogene family	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants
RAP1GDS1	Rap1 GTPase-GDP dissociation stimulator 1	RHOT2 GTPase cycle RHOT1 GTPase cycle
RAPGEF1	Rap guanine nucleotide exchange factor 1	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
RASA1	RAS p21 protein activator 1	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases		RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
RASA2	RAS p21 protein activator 2	Regulation of RAS by GAPs
RASA4	RAS p21 protein activator 4	Regulation of RAS by GAPs
RASGRF1	Ras protein specific guanine nucleotide releasing factor 1	Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
RASGRP1	RAS guanyl releasing protein 1	Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade
RASGRP4	RAS guanyl releasing protein 4	FCERI mediated NF-kB activation RAF/MAP kinase cascade
RASIP1	Ras interacting protein 1
RASSF1	Ras association domain family member 1			Nasopharyngeal cancer Non-small cell lung cancer Bladder cancer
RASSF2	Ras association domain family member 2
RASSF5	Ras association domain family member 5

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