APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
APBB3	amyloid beta precursor protein binding family B member 3
APEX1	apurinic/apyrimidinic endodeoxyribonuclease 1	Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)	Lucanthone
APEX2	apurinic/apyrimidinic endodeoxyribonuclease 2
APLF	aprataxin and PNKP like factor
APOA1	apolipoprotein A1	Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Hypoalphalipoproteinemia Familial amyloidosis
APOBEC3G	apolipoprotein B mRNA editing enzyme catalytic subunit 3G
APOBEC3H	apolipoprotein B mRNA editing enzyme catalytic subunit 3H	mRNA Editing: C to U Conversion Formation of the Editosome
APOE	apolipoprotein E	Nuclear signaling by ERBB4 Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Alzheimer's disease (AD) Hyperlipoproteinemia, type III; Dysbetalipoproteinemia Lipoprotein glomerulopathy
APPBP2	amyloid beta precursor protein binding protein 2
APRT	adenine phosphoribosyltransferase	Neutrophil degranulation Purine salvage Defective APRT disrupts adenine salvage	Adenine 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5H-pyrrolo[3,2-d]pyrimidin-4-amine Citric acid	Adenine phosphoribosyltransferase deficiency; 2,8-Dihydroxyadenine urolithiasis
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
ARCN1	archain 1 coat protein complex I subunit delta	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
AREG	amphiregulin	PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling NFE2L2 regulating tumorigenic genes Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells
ARF6	ARF GTPase 6	TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
ARFGAP1	ARF GTPase activating protein 1	XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
ARFGAP3	ARF GTPase activating protein 3	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic CDC42 GTPase cycle RHOG GTPase cycle
ARFIP2	ARF interacting protein 2	Retrograde transport at the Trans-Golgi-Network
ARGLU1	arginine and glutamate rich 1
ARHGAP15	Rho GTPase activating protein 15	RAC1 GTPase cycle RAC3 GTPase cycle
ARHGAP17	Rho GTPase activating protein 17	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RAC3 GTPase cycle

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