Search Results for: APP

2116 interactions involving APP - amyloid beta precursor protein found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
NDUFA2 NADH:ubiquinone oxidoreductase subunit A2
  • Respiratory electron transport
  • Complex I biogenesis
  • Mitochondrial protein degradation
  • NADH
NDUFA5 NADH:ubiquinone oxidoreductase subunit A5
  • Respiratory electron transport
  • Complex I biogenesis
  • RHOG GTPase cycle
  • NADH
NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7
  • Complex I biogenesis
NDUFB1 NADH:ubiquinone oxidoreductase subunit B1
  • Respiratory electron transport
  • Complex I biogenesis
  • NADH
NDUFB3 NADH:ubiquinone oxidoreductase subunit B3
  • Respiratory electron transport
  • Complex I biogenesis
  • NADH
NDUFB6 NADH:ubiquinone oxidoreductase subunit B6
  • Respiratory electron transport
  • Complex I biogenesis
  • Mitochondrial protein degradation
  • NADH
NDUFS2 NADH:ubiquinone oxidoreductase core subunit S2
  • Respiratory electron transport
  • Complex I biogenesis
  • NADH
  • Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
NDUFS4 NADH:ubiquinone oxidoreductase subunit S4
  • Respiratory electron transport
  • Complex I biogenesis
  • NADH
  • Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
NECAB1 N-terminal EF-hand calcium binding protein 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NECAP1 NECAP endocytosis associated 1
  • Golgi Associated Vesicle Biogenesis
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
NECAP2 NECAP endocytosis associated 2
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEIL1 nei like DNA glycosylase 1
  • Recognition and association of DNA glycosylase with site containing an affected pyrimidine
  • Cleavage of the damaged pyrimidine
  • APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
  • Defective Base Excision Repair Associated with NEIL1
  • Iron
  • Copper
  • Ferrous gluconate
  • Ferrous succinate
  • Ferrous ascorbate
  • Ferrous fumarate
  • Ferrous glycine sulfate
NEK11 NIMA related kinase 11
  • Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
  • Dabrafenib
  • Fostamatinib
NELFA negative elongation factor complex member A
  • Formation of RNA Pol II elongation complex
  • Formation of the Early Elongation Complex
  • Formation of HIV elongation complex in the absence of HIV Tat
  • Formation of the HIV-1 Early Elongation Complex
  • Formation of HIV-1 elongation complex containing HIV-1 Tat
  • Formation of HIV-1 elongation complex containing HIV-1 Tat
  • Pausing and recovery of Tat-mediated HIV elongation
  • Abortive elongation of HIV-1 transcript in the absence of Tat
  • Tat-mediated HIV elongation arrest and recovery
  • Tat-mediated elongation of the HIV-1 transcript
  • HIV elongation arrest and recovery
  • Pausing and recovery of HIV elongation
  • RNA Polymerase II Pre-transcription Events
  • TP53 Regulates Transcription of DNA Repair Genes
  • RNA Polymerase II Transcription Elongation
NF1 neurofibromin 1
  • Regulation of RAS by GAPs
  • RAS signaling downstream of NF1 loss-of-function variants
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
NFKBIB NFKB inhibitor beta
  • Activation of NF-kappaB in B cells
  • RIP-mediated NFkB activation via ZBP1
  • TAK1-dependent IKK and NF-kappa-B activation
  • TRAF6 mediated NF-kB activation
NFYA nuclear transcription factor Y subunit alpha
  • PPARA activates gene expression
  • Activation of gene expression by SREBF (SREBP)
  • Activation of gene expression by SREBF (SREBP)
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • ATF6 (ATF6-alpha) activates chaperone genes
  • ATF6 (ATF6-alpha) activates chaperone genes
  • FOXO-mediated transcription of cell death genes
NGFR nerve growth factor receptor
  • Axonal growth inhibition (RHOA activation)
  • NRAGE signals death through JNK
  • p75NTR negatively regulates cell cycle via SC1
  • Ceramide signalling
  • Regulated proteolysis of p75NTR
  • NFG and proNGF binds to p75NTR
  • NADE modulates death signalling
  • NRIF signals cell death from the nucleus
  • NRIF signals cell death from the nucleus
  • p75NTR recruits signalling complexes
  • p75NTR recruits signalling complexes
  • NF-kB is activated and signals survival
  • Axonal growth stimulation

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