UBC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
USP45	ubiquitin specific peptidase 45	Formation of Incision Complex in GG-NER
USP46	ubiquitin specific peptidase 46
USP47	ubiquitin specific peptidase 47	Ub-specific processing proteases
USP48	ubiquitin specific peptidase 48	Ub-specific processing proteases
USP53	ubiquitin specific peptidase 53
USP54	ubiquitin specific peptidase 54
USP6	ubiquitin specific peptidase 6
USP7	ubiquitin specific peptidase 7	Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization
USP8	ubiquitin specific peptidase 8	Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity
USP9X	ubiquitin specific peptidase 9 X-linked	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
USP9Y	ubiquitin specific peptidase 9 Y-linked			Azoospermia, including: Azoospermia; Azoospermia due to perturbations of meiosis
VANGL1	VANGL planar cell polarity protein 1	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle		Spina bifida Caudal regression syndrome and Sirenomelia
VBP1	VHL binding protein 1	Prefoldin mediated transfer of substrate to CCT/TriC
VCF1	VCP nuclear cofactor family member 1
VCP	valosin containing protein	Translesion Synthesis by POLH HSF1 activation ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis Josephin domain DUBs Ovarian tumor domain proteases Neutrophil degranulation E3 ubiquitin ligases ubiquitinate target proteins Protein methylation Neddylation RHOH GTPase cycle Aggrephagy Attachment and Entry Attachment and Entry KEAP1-NFE2L2 pathway AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Phosphoaminophosphonic Acid-Adenylate Ester Phenethyl Isothiocyanate	Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
VCPIP1	valosin containing protein interacting protein 1	Ovarian tumor domain proteases
VIM	vimentin	Caspase-mediated cleavage of cytoskeletal proteins Striated Muscle Contraction Interleukin-4 and Interleukin-13 signaling RHOBTB1 GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Developmental Lineage of Mammary Gland Myoepithelial Cells	Artenimol Phenethyl Isothiocyanate
VPS16	VPS16 core subunit of CORVET and HOPS complexes	SARS-CoV-2 modulates autophagy
VPS25	vacuolar protein sorting 25 homolog	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
VPS28	VPS28 subunit of ESCRT-I	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy

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