APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
LINGO2	leucine rich repeat and Ig domain containing 2
LIPT1	lipoyltransferase 1	Protein lipoylation	Lipoic acid
LLPH	LLP homolog, long-term synaptic facilitation factor
LMAN1	lectin, mannose binding 1	COPII-mediated vesicle transport Cargo concentration in the ER RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Transport to the Golgi and subsequent modification	Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa	Combined deficiency of factors V and VIII (F5F8D)
LMCD1	LIM and cysteine rich domains 1	Surfactant metabolism
LMF2	lipase maturation factor 2	Assembly of active LPL and LIPC lipase complexes
LMNTD1	lamin tail domain containing 1
LMX1B	LIM homeobox transcription factor 1 beta			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
LNX1	ligand of numb-protein X 1	Antigen processing: Ubiquitination & Proteasome degradation
LPAR3	lysophosphatidic acid receptor 3	G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
LPL	lipoprotein lipase	Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Tyloxapol Omega-3-carboxylic acids Glycyrrhizic acid	Hyperlipoproteinemia, type I
LRP1	LDL receptor related protein 1	Scavenging of heme from plasma Retinoid metabolism and transport	Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Von Willebrand factor human Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa
LRP1B	LDL receptor related protein 1B
LRP2	LDL receptor related protein 2	Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body	Urokinase Insulin human	Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
LRRC1	leucine rich repeat containing 1	RND2 GTPase cycle
LRRC42	leucine rich repeat containing 42
LRRC66	leucine rich repeat containing 66
LRRC8D	leucine rich repeat containing 8 VRAC subunit D	Miscellaneous transport and binding events		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
LRRK2	leucine rich repeat kinase 2	PTK6 promotes HIF1A stabilization	Fostamatinib	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
LSM6	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	Uridine Uridine monophosphate Citric acid

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