UBC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
UBE2O	ubiquitin conjugating enzyme E2 O	Antigen processing: Ubiquitination & Proteasome degradation
UBE2Q1	ubiquitin conjugating enzyme E2 Q1	Antigen processing: Ubiquitination & Proteasome degradation
UBE2Q2	ubiquitin conjugating enzyme E2 Q2	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
UBE2R2	ubiquitin conjugating enzyme E2 R2	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
UBE2S	ubiquitin conjugating enzyme E2 S	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
UBE2T	ubiquitin conjugating enzyme E2 T	Fanconi Anemia Pathway Synthesis of active ubiquitin: roles of E1 and E2 enzymes
UBE2V1	ubiquitin conjugating enzyme E2 V1	NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
UBE2V2	ubiquitin conjugating enzyme E2 V2	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
UBE3A	ubiquitin protein ligase E3A	Antigen processing: Ubiquitination & Proteasome degradation		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
UBFD1	ubiquitin family domain containing 1
UBL7	ubiquitin like 7
UBQLN1	ubiquilin 1	Cargo recognition for clathrin-mediated endocytosis
UBQLN2	ubiquilin 2	Cargo recognition for clathrin-mediated endocytosis
UBQLN4	ubiquilin 4
UBR4	ubiquitin protein ligase E3 component n-recognin 4	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Verpasep caltespen Picolinic acid
UBXN1	UBX domain protein 1	N-glycan trimming in the ER and Calnexin/Calreticulin cycle Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UBXN2B	UBX domain protein 2B
UBXN6	UBX domain protein 6
UBXN7	UBX domain protein 7	Neddylation KEAP1-NFE2L2 pathway
UCHL1	ubiquitin C-terminal hydrolase L1	UCH proteinases	Phenethyl Isothiocyanate	Parkinson's disease (PD)

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