Search Results for: APP

2116 interactions involving APP - amyloid beta precursor protein found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
JTB jumping translocation breakpoint
JUN Jun proto-oncogene, AP-1 transcription factor subunit
  • Pre-NOTCH Transcription and Translation
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • FCERI mediated MAPK activation
  • Activation of the AP-1 family of transcription factors
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • MAPK6/MAPK4 signaling
  • TP53 Regulates Transcription of DNA Repair Genes
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Regulation of PTEN gene transcription
  • Regulation of PTEN gene transcription
  • Estrogen-dependent gene expression
  • WNT5:FZD7-mediated leishmania damping
  • Signaling by ALK fusions and activated point mutants
  • Regulation of PD-L1(CD274) transcription
  • Adapalene
  • Vinblastine
  • Pseudoephedrine
  • Irbesartan
  • Arsenic trioxide
  • LGD-1550
KANSL2 KAT8 regulatory NSL complex subunit 2
  • HATs acetylate histones
  • Formation of WDR5-containing histone-modifying complexes
KAT5 lysine acetyltransferase 5
  • Formation of the beta-catenin:TCF transactivating complex
  • Formation of the beta-catenin:TCF transactivating complex
  • DNA Damage/Telomere Stress Induced Senescence
  • HATs acetylate histones
  • HDR through Single Strand Annealing (SSA)
  • HDR through Homologous Recombination (HRR)
  • Sensing of DNA Double Strand Breaks
  • Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Resolution of D-loop Structures through Holliday Junction Intermediates
  • Nonhomologous End-Joining (NHEJ)
  • Homologous DNA Pairing and Strand Exchange
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Estrogen-dependent gene expression
  • Defective homologous recombination repair (HRR) due to BRCA1 loss of function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
  • Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
  • Impaired BRCA2 binding to RAD51
  • Impaired BRCA2 binding to PALB2
  • Cardiogenesis
  • Coenzyme A
  • S-Acetyl-Cysteine
KAT7 lysine acetyltransferase 7
  • HATs acetylate histones
KATNA1 katanin catalytic subunit A1
KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1
  • Voltage gated Potassium channels
  • Enflurane
  • Promethazine
  • Miconazole
KCNAB3 potassium voltage-gated channel subfamily A regulatory beta subunit 3
  • Voltage gated Potassium channels
KCNE5 potassium voltage-gated channel subfamily E regulatory subunit 5
  • Phase 3 - rapid repolarisation
  • Phase 2 - plateau phase
  • Enflurane
  • Promethazine
  • Miconazole
KCNIP4 potassium voltage-gated channel interacting protein 4
  • Phase 1 - inactivation of fast Na+ channels
KCNJ10 potassium inwardly rectifying channel subfamily J member 10
  • Activation of G protein gated Potassium channels
  • Potassium transport channels
  • Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
  • Ritodrine
  • Yohimbine
  • Butamben
  • Seizures-sensorineural deafness-ataxia-mental retardation-electrolyte imbalance (SESAME) ; SeSAME/EAST syndrome
KCNJ5-AS1 KCNJ5 antisense RNA 1
KCNK5 potassium two pore domain channel subfamily K member 5
  • Phase 4 - resting membrane potential
KCNMB2 potassium calcium-activated channel subfamily M regulatory beta subunit 2
  • Ca2+ activated K+ channels
  • cGMP effects
  • Procaine
  • Ritodrine
  • Nitrendipine
  • Miconazole
  • Colforsin
  • (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidine
  • Trimebutine
KCNN3 potassium calcium-activated channel subfamily N member 3
  • Ca2+ activated K+ channels
  • Procaine
  • Ritodrine
  • Nitrendipine
  • Miconazole
  • Colforsin
  • Dequalinium
  • Trimebutine
  • Rimtuzalcap
KCTD18 potassium channel tetramerization domain containing 18
KIAA0319 KIAA0319
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
KIAA0513 KIAA0513
KIAA0825 KIAA0825
KIAA0930 KIAA0930

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