UBC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
TMX3	thioredoxin related transmembrane protein 3	Platelet degranulation
TNFAIP3	TNF alpha induced protein 3	NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
TNFAIP6	TNF alpha induced protein 6	Neutrophil degranulation	Donepezil Acetylsalicylic acid Hyaluronic acid
TNIP1	TNFAIP3 interacting protein 1	Ovarian tumor domain proteases
TNIP2	TNFAIP3 interacting protein 2	MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases
TNIP3	TNFAIP3 interacting protein 3	Ovarian tumor domain proteases
TNK1	tyrosine kinase non receptor 1		Fostamatinib
TNK2	tyrosine kinase non receptor 2	Signaling by LTK	ATP Debromohymenialdisine Entrectinib Fostamatinib
TNNC1	troponin C1, slow skeletal and cardiac type	Striated Muscle Contraction	Trifluoperazine Levosimendan Felodipine Bepridil Calcium Aluminium monostearate 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
TNRC6A	trinucleotide repeat containing adaptor 6A	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
TNRC6C	trinucleotide repeat containing adaptor 6C	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
TOM1	target of myb1 membrane trafficking protein	Neutrophil degranulation
TOM1L1	target of myb1 like 1 membrane trafficking protein
TOM1L2	target of myb1 like 2 membrane trafficking protein
TOP1MT	DNA topoisomerase I mitochondrial		Irinotecan Topotecan
TOP2B	DNA topoisomerase II beta	SUMOylation of DNA replication proteins	Dexrazoxane Daunorubicin Etoposide Dactinomycin Doxorubicin Norfloxacin Phosphoaminophosphonic Acid-Adenylate Ester Amonafide Technetium Tc-99m ciprofloxacin ZEN-012 Becatecarin Declopramide 3'-THIO-THYMIDINE-5'-PHOSPHATE
TOPORS	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins		Retinitis pigmentosa (RP)
TOR1AIP2	torsin 1A interacting protein 2
TOR4A	torsin family 4 member A	Platelet degranulation
TP53BP2	tumor protein p53 binding protein 2	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors

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