UBC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
TDP1	tyrosyl-DNA phosphodiesterase 1	Nonhomologous End-Joining (NHEJ)		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
TDRD3	tudor domain containing 3
TEDC1	tubulin epsilon and delta complex 1
TENT4A	terminal nucleotidyltransferase 4A	Signaling by BRAF and RAF1 fusions Nuclear RNA decay
TFDP1	transcription factor Dp-1	Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria G0 and Early G1 Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
TGFB1	transforming growth factor beta 1	Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions ECM proteoglycans SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Transcriptional regulation of white adipocyte differentiation UCH proteinases Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF TGFBR3 regulates TGF-beta signaling	Hyaluronidase (ovine) Terazosin Hyaluronidase (human recombinant) Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Hyaluronidase	Graft-versus-host disease Allograft rejection Camurati-Engelmann disease; Progressive diaphyseal dysplasia
THBS2	thrombospondin 2	Signaling by PDGF Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
THG1L	tRNA-histidine guanylyltransferase 1 like	tRNA modification in the nucleus and cytosol
THYN1	thymocyte nuclear protein 1
TIAM1	TIAM Rac1 associated GEF 1	NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5
TIMP1	TIMP metallopeptidase inhibitor 1	Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation TGFBR3 PTM regulation
TK1	thymidine kinase 1	G1/S-Specific Transcription Pyrimidine salvage	Dithioerythritol Thymidine 5'-triphosphate
TK2	thymidine kinase 2	Pyrimidine salvage	Thymidine 5'-triphosphate 2'-Deoxycytidine Brivudine Thymidine	Mitochondrial DNA depletion syndrome (MDS)
TMED3	transmembrane p24 trafficking protein 3	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
TMEM120A	transmembrane protein 120A
TMEM126B	transmembrane protein 126B	Complex I biogenesis
TMEM132A	transmembrane protein 132A	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
TMEM160	transmembrane protein 160
TMEM201	transmembrane protein 201
TMEM223	transmembrane protein 223	Complex IV assembly

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