APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HTRA2	HtrA serine peptidase 2	Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)		Parkinson's disease (PD)
HYCC2	hyccin PI4KA lipid kinase complex subunit 2
IARS1	isoleucyl-tRNA synthetase 1	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Isoleucine
IARS2	isoleucyl-tRNA synthetase 2, mitochondrial	Mitochondrial tRNA aminoacylation Mitochondrial protein degradation	Isoleucine
ICAM3	intercellular adhesion molecule 3	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
IDE	insulin degrading enzyme	Ub-specific processing proteases Insulin receptor recycling Peroxisomal protein import Peroxisomal protein import	Bacitracin
IDO1	indoleamine 2,3-dioxygenase 1	Tryptophan catabolism	Nitric Oxide Cannabidiol Medical Cannabis Nabiximols
IER3	immediate early response 3	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IFI16	interferon gamma inducible protein 16	STING mediated induction of host immune responses IRF3-mediated induction of type I IFN
IFI6	interferon alpha inducible protein 6	Interferon alpha/beta signaling Modulation of host responses by IFN-stimulated genes
IFIH1	interferon induced with helicase C domain 1	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses Modulation of host responses by IFN-stimulated genes		Type I diabetes mellitus
IFNA16	interferon alpha 16	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
IFNA5	interferon alpha 5	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
IFNA8	interferon alpha 8	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
IFNW1	interferon omega 1
IFRD2	interferon related developmental regulator 2
IFT81	intraflagellar transport 81	Intraflagellar transport Intraflagellar transport
IGBP1	immunoglobulin binding protein 1			Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia
IGF1R	insulin like growth factor 1 receptor	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling Respiratory syncytial virus (RSV) attachment and entry	Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Phosphoaminophosphonic Acid-Adenylate Ester ATL1101 XL228 rhIGFBP-3 Linsitinib Teprotumumab (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE Nandrolone decanoate Somatrem Insulin beef Insulin degludec Insulin argine Insulin peglispro Insulin tregopil Dalotuzumab Cixutumumab Brigatinib Mecasermin rinfabate BMS-754807 KW-2450 free base	Synovial sarcoma Malignant pleural mesothelioma
IGHM	immunoglobulin heavy constant mu

Search Results for: APP