APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HMGB4	high mobility group box 4
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2	PPARA activates gene expression Synthesis of Ketone Bodies Mitochondrial protein degradation		HMG-CoA synthase (HMGCS) deficiency
HMOX2	heme oxygenase 2	Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1	NADH Stannsoporfin
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA SARS-CoV-1-host interactions SARS-CoV-1 modulates host translation machinery
HOMER2	homer scaffold protein 2	Neurexins and neuroligins Neurexins and neuroligins
HOMER3	homer scaffold protein 3	Neurexins and neuroligins Neurexins and neuroligins
HOXB7	homeobox B7
HOXC4	homeobox C4	Activation of anterior HOX genes in hindbrain development during early embryogenesis
HOXC6	homeobox C6
HP1BP3	heterochromatin protein 1 binding protein 3		Artenimol
HPGD	15-hydroxyprostaglandin dehydrogenase	Biosynthesis of Lipoxins (LX) Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Biosynthesis of D-series resolvins Biosynthesis of E-series 18(S)-resolvins	NADH	Primary hypertrophic osteoarthropathy (PHO)
HS3ST1	heparan sulfate-glucosamine 3-sulfotransferase 1	HS-GAG biosynthesis	Adenosine 3',5'-diphosphate
HSD17B10	hydroxysteroid 17-beta dehydrogenase 10	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion Mitochondrial protein degradation	NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids	Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH) 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
HSPA13	heat shock protein family A (Hsp70) member 13	Regulation of HSF1-mediated heat shock response	Copper
HSPA2	heat shock protein family A (Hsp70) member 2	Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase PKR-mediated signaling	Quercetin
HSPA9	heat shock protein family A (Hsp70) member 9	Mitochondrial protein import Regulation of HSF1-mediated heat shock response Complex I biogenesis Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt) Complex III assembly
HSPB7	heat shock protein family B (small) member 7
HSPBP1	HSPA (Hsp70) binding protein 1
HSPD1	heat shock protein family D (Hsp60) member 1	Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Copper	Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
HSPG2	heparan sulfate proteoglycan 2	Degradation of the extracellular matrix Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Formation of the dystrophin-glycoprotein complex (DGC)	Palifermin	Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses

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