APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HDDC3	HD domain containing 3
HDGF	heparin binding growth factor	XBP1(S) activates chaperone genes	Copper
HELLS	helicase, lymphoid specific	TGFBR3 expression
HERC2P9	HERC2 pseudogene 9
HERPUD1	homocysteine inducible ER protein with ubiquitin like domain 1	ATF4 activates genes in response to endoplasmic reticulum stress
HEYL	hes related family bHLH transcription factor with YRPW motif like	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Intracellular Domain Regulates Transcription Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Citric acid
HIC2	HIC ZBTB transcriptional repressor 2
HIGD2A	HIG1 hypoxia inducible domain family member 2A	Complex IV assembly
HIKESHI	heat shock protein nuclear import factor hikeshi	Regulation of HSF1-mediated heat shock response
HINT2	histidine triad nucleotide binding protein 2	RHOD GTPase cycle
HINT3	histidine triad nucleotide binding protein 3
HIRIP3	HIRA interacting protein 3
HK1	hexokinase 1	Synthesis of GDP-mannose Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis	alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine	Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
HMBOX1	homeobox containing 1
HMBS	hydroxymethylbilane synthase	Heme biosynthesis		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
HMCES	5-hydroxymethylcytosine binding, ES cell specific
HMG20B	high mobility group 20B	HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
HMGA1	high mobility group AT-hook 1	Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF)
HMGB2	high mobility group box 2	Apoptosis induced DNA fragmentation

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