USP2 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HOMER3	homer scaffold protein 3	Neurexins and neuroligins Neurexins and neuroligins
HOOK1	hook microtubule tethering protein 1
HOOK2	hook microtubule tethering protein 2
IHO1	interactor of HORMAD1 1
IKBKG	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes	AGRO100 Tarenflurbil	Incontinentia pigmenti Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
IKZF3	IKAROS family zinc finger 3
IL1RL2	interleukin 1 receptor like 2	Interleukin-38 signaling Interleukin-36 pathway	Spesolimab
INTS11	integrator complex subunit 11	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
JAKMIP1	janus kinase and microtubule interacting protein 1
JRK	Jrk helix-turn-helix protein
KAZN	kazrin, periplakin interacting protein	Formation of the cornified envelope
KIFC3	kinesin family member C3
KRT15	keratin 15	Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
KRT27	keratin 27	Keratinization Formation of the cornified envelope
KRT31	keratin 31	Keratinization Formation of the cornified envelope
KRT33B	keratin 33B	Keratinization Formation of the cornified envelope
KRT34	keratin 34	Keratinization Formation of the cornified envelope
KRT35	keratin 35	Keratinization Formation of the cornified envelope
KRT40	keratin 40	Keratinization Formation of the cornified envelope
LHX3	LIM homeobox 3	Regulation of expression of SLITs and ROBOs		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)

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