TK1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
F13A1	coagulation factor XIII A chain	Platelet degranulation Common Pathway of Fibrin Clot Formation Interleukin-4 and Interleukin-13 signaling	N-Acetyl-Serine Thrombin Prothrombin Human thrombin Anti-inhibitor coagulant complex	Factor XIII deficiency
FAF1	Fas associated factor 1
FAM20C	FAM20C golgi associated secretory pathway kinase	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation		Raine syndrome; Lethal osteosclerotic bone dysplasia
FBN3	fibrillin 3	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
FGB	fibrinogen beta chain	Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Sucralfate Alfimeprase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex	Inherited thrombophilia Afibrinogenemia; Dysfibrinogenemia
FLAD1	flavin adenine dinucleotide synthetase 1	Vitamin B2 (riboflavin) metabolism
FST	follistatin	Antagonism of Activin by Follistatin	D-Myo-Inositol-Hexasulphate
FZR1	fizzy and cell division cycle 20 related 1	Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	Glycolysis Gluconeogenesis	NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper Artenimol
GDF9	growth differentiation factor 9
GDI1	GDP dissociation inhibitor 1	RAB GEFs exchange GTP for GDP on RABs		Non-syndromic X-linked mental retardation
GET3	guided entry of tail-anchored proteins factor 3, ATPase	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	ATP
GLB1	galactosidase beta 1	Keratan sulfate degradation CS/DS degradation MPS IV - Morquio syndrome B (Keratin metabolism) Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism MPS IV - Morquio syndrome B (CS/DS degradation)	Lactose	Mucopolysaccharidosis type IV (MPS4), including: Morquio syndrome A (MPS4A); Morquio syndrome B (MPS4B) Galactosialidosis GM1 gangliosidosis
GPCPD1	glycerophosphocholine phosphodiesterase 1	Hydrolysis of LPC Hydrolysis of LPE
HADHB	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA
HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	Antigen processing: Ubiquitination & Proteasome degradation
HMGXB3	HMG-box containing 3
HSPBAP1	HSPB1 associated protein 1
IER3IP1	immediate early response 3 interacting protein 1
IGHM	immunoglobulin heavy constant mu

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