PRKCA - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
FBXO25	F-box protein 25
FBXO7	F-box protein 7	Neddylation Antigen processing: Ubiquitination & Proteasome degradation		Parkinson's disease (PD)
FCGR2B	Fc gamma receptor IIb	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Etanercept Human immunoglobulin G Abciximab Tositumomab Alemtuzumab Antithymocyte immunoglobulin (rabbit) Palivizumab Daclizumab Bevacizumab Sarilumab	Systemic lupus erythematosus
FCGR3A	Fc gamma receptor IIIa	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Alefacept Palivizumab Daclizumab Bevacizumab Catumaxomab Sarilumab Benralizumab Amivantamab	NK cell defects, including the following disease: CD16 deficiency Systemic lupus erythematosus
FLNA	filamin A	Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	Artenimol	FG syndrome (FGS); Opitz-Kaveggia syndrome Periventricular nodular heterotopia (PVNH) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
FLNC	filamin C	Cell-extracellular matrix interactions		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
FSCN1	fascin actin-bundling protein 1	Interleukin-4 and Interleukin-13 signaling
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3	Signaling by ERBB4 GABA receptor activation GABA receptor activation	Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Piperazine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Muscimol 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2	Signaling by ERBB4 GABA receptor activation GABA receptor activation	Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Alprazolam Zolpidem Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Camazepam Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam	Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GABRR1	gamma-aminobutyric acid type A receptor subunit rho1	GABA receptor activation	Lindane Picrotoxin Fludiazepam TPMPA
GABRR2	gamma-aminobutyric acid type A receptor subunit rho2	GABA receptor activation	Fludiazepam TPMPA
GFAP	glial fibrillary acidic protein	Nuclear signaling by ERBB4 Chaperone Mediated Autophagy		Alexander disease
GFPT1	glutamine--fructose-6-phosphate transaminase 1	XBP1(S) activates chaperone genes Defective GFPT1 causes CMSTA1 Synthesis of UDP-N-acetyl-glucosamine
GJA1	gap junction protein alpha 1	Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly Gap junction assembly Gap junction degradation Regulation of gap junction activity Regulation of gap junction activity Formation of annular gap junctions RHOQ GTPase cycle RHOJ GTPase cycle SARS-CoV-2 targets PDZ proteins in cell-cell junction Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Carvedilol	Deafness, autosomal recessive Oculodentodigital dysplasia Syndactyly
GJB1	gap junction protein beta 1	Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GLI3	GLI family zinc finger 3	GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates osteoblast differentiation		Acrocallosal syndrome; Greig cephalopolysyndactyly syndrome Pallister-Hall syndrome
GMFB	glia maturation factor beta
GNA12	G protein subunit alpha 12	G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
GNA15	G protein subunit alpha 15	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
GPM6A	glycoprotein M6A

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