DAXX - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	MAP3K5	mitogen-activated protein kinase kinase kinase 5	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
Novel	MCRS1	microspherule protein 1	HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes
Novel	MDM2	MDM2 proto-oncogene	AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity Signaling by ALK fusions and activated point mutants Degradation of CDH1 NPAS4 regulates expression of target genes	Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Penile cancer Alveolar rhabdomyosarcoma Choriocarcinoma Osteosarcoma Glioma
Novel	MEN1	menin 1	Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation Formation of WDR5-containing histone-modifying complexes		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Adrenal carcinoma Malignant islet cell carcinoma Carcinoid
Novel	MIPOL1	mirror-image polydactyly 1
Novel	MKRN1	makorin ring finger protein 1	AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Novel	MSANTD4	Myb/SANT DNA binding domain containing 4 with coiled-coils
Novel	MX1	MX dynamin like GTPase 1	ISG15 antiviral mechanism Interferon alpha/beta signaling
Novel	MYH11	myosin heavy chain 11	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Developmental Lineage of Mammary Gland Myoepithelial Cells	Tetrafluoroaluminate Ion	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
Novel	NECAB2	N-terminal EF-hand calcium binding protein 2
Novel	NRG2	neuregulin 2	Signaling by ERBB2 Signaling by ERBB4 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Novel	NSD3	nuclear receptor binding SET domain protein 3	PKMTs methylate histone lysines
Novel	PARK7	Parkinsonism associated deglycase	SUMOylation of transcription cofactors Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Copper	Parkinson's disease (PD)
Novel	PAX3	paired box 3	HATs acetylate histones Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity Transcriptional and post-translational regulation of MITF-M expression and activity		Alveolar rhabdomyosarcoma Waardenburg syndrome (WS) Craniofacial-deafness-hand syndrome
Novel	PAX5	paired box 5	RUNX1 regulates transcription of genes involved in BCR signaling		Lymphoplasmacytic lymphoma
Novel	PBXIP1	PBX homeobox interacting protein 1
Novel	PIBF1	progesterone immunomodulatory binding factor 1
Novel	PLAGL1	PLAG1 like zinc finger 1	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain		Transient neonatal diabetes mellitus (TNDM)
Novel	PML	PML nuclear body scaffold	SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events	Arsenic trioxide	Acute myeloid leukemia (AML)
Novel	PNMA1	PNMA family member 1

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