ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
DAZAP2	DAZ associated protein 2
DCTN3	dynactin subunit 3	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
DHRSX	dehydrogenase/reductase X-linked	Synthesis of dolichyl-phosphate
DHX37	DEAH-box helicase 37	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
DIXDC1	DIX domain containing 1
DMPK	DM1 protein kinase	Ion homeostasis	Bisindolylmaleimide VIII	Myotonic dystrophy (DM)
DNAJA3	DnaJ heat shock protein family (Hsp40) member A3
DOCK5	dedicator of cytokinesis 5	RAC1 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
DZIP3	DAZ interacting zinc finger protein 3	Antigen processing: Ubiquitination & Proteasome degradation
EFEMP2	EGF-like fibulin extracellular matrix protein 2	Molecules associated with elastic fibres Molecules associated with elastic fibres		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
EHMT1	euchromatic histone lysine methyltransferase 1	Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex		Kleefstra syndrome; 9q Subtelomeric deletion syndrome
EIF1AY	eukaryotic translation initiation factor 1A Y-linked
EIF1B	eukaryotic translation initiation factor 1B
EIF3F	eukaryotic translation initiation factor 3 subunit F	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Quercetin
EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1
ELP5	elongator acetyltransferase complex subunit 5	HATs acetylate histones
EML3	EMAP like 3
ENTPD6	ectonucleoside triphosphate diphosphohydrolase 6	Phosphate bond hydrolysis by NTPDase proteins
EPN2	epsin 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
ESRP1	epithelial splicing regulatory protein 1	Signaling by BRAF and RAF1 fusions FGFR2 alternative splicing

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