ATXN1 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	DHX37	DEAH-box helicase 37	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Novel	DIXDC1	DIX domain containing 1
Novel	DMPK	DM1 protein kinase	Ion homeostasis	Bisindolylmaleimide VIII	Myotonic dystrophy (DM)
Novel	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3
Novel	DOCK5	dedicator of cytokinesis 5	RAC1 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
Novel	DZIP3	DAZ interacting zinc finger protein 3	Antigen processing: Ubiquitination & Proteasome degradation
Novel	EFEMP2	EGF-like fibulin extracellular matrix protein 2	Molecules associated with elastic fibres Molecules associated with elastic fibres		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
Novel	EHMT1	euchromatic histone lysine methyltransferase 1	Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex		Kleefstra syndrome; 9q Subtelomeric deletion syndrome
Novel	EIF1AY	eukaryotic translation initiation factor 1A Y-linked
Novel	EIF1B	eukaryotic translation initiation factor 1B
Novel	EIF3F	eukaryotic translation initiation factor 3 subunit F	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Quercetin
Novel	EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1
Novel	ELP5	elongator acetyltransferase complex subunit 5	HATs acetylate histones
Novel	EML3	EMAP like 3
Novel	ENTPD6	ectonucleoside triphosphate diphosphohydrolase 6	Phosphate bond hydrolysis by NTPDase proteins
Novel	EPN2	epsin 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Novel	ESRP1	epithelial splicing regulatory protein 1	Signaling by BRAF and RAF1 fusions FGFR2 alternative splicing
Novel	ESRRA	estrogen related receptor alpha	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity	Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone
Novel	ETV4	ETS variant transcription factor 4	MAPK6/MAPK4 signaling		Prostate cancer Ewing's sarcoma
Novel	EXTL3	exostosin like glycosyltransferase 3	HS-GAG biosynthesis XBP1(S) activates chaperone genes

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