Search Results for: PTEN

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
SKP1 S-phase kinase associated protein 1
  • Activation of NF-kappaB in B cells
  • Prolactin receptor signaling
  • SCF-beta-TrCP mediated degradation of Emi1
  • Vpu mediated degradation of CD4
  • SCF(Skp2)-mediated degradation of p27/p21
  • Degradation of beta-catenin by the destruction complex
  • Downstream TCR signaling
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Regulation of PLK1 Activity at G2/M Transition
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
  • FCERI mediated NF-kB activation
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • Dectin-1 mediated noncanonical NF-kB signaling
  • CLEC7A (Dectin-1) signaling
  • Degradation of GLI1 by the proteasome
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • NIK-->noncanonical NF-kB signaling
  • MAP3K8 (TPL2)-dependent MAPK1/3 activation
  • Orc1 removal from chromatin
  • Cyclin D associated events in G1
  • Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
  • FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
  • Regulation of RUNX2 expression and activity
  • Neddylation
  • Interleukin-1 signaling
  • Iron uptake and transport
  • Negative regulation of NOTCH4 signaling
  • Regulation of BACH1 activity
  • Nuclear events stimulated by ALK signaling in cancer
  • GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
  • Antigen processing: Ubiquitination & Proteasome degradation
  • GSK3B-mediated proteasomal degradation of PD-L1(CD274)
  • Degradation of CRY and PER proteins
  • 1-naphthaleneacetic acid
  • (2S)-2-(1H-indol-3-yl)hexanoic acid
  • (2S)-2-(1H-indol-3-yl)pentanoic acid
  • (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
  • Indoleacetic acid
SLC25A1 solute carrier family 25 member 1
  • Organic anion transport by SLC5/17/25 transporters
SLC25A13 solute carrier family 25 member 13
  • Mitochondrial protein import
  • Aspartate and asparagine metabolism
  • Malate-aspartate shuttle
  • Aspartic acid
  • Citrullinemia (CTLN)
SLC25A3 solute carrier family 25 member 3
SLC25A5 solute carrier family 25 member 5
  • Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
  • Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
  • Mitochondrial protein degradation
  • Clodronic acid
  • Etidronic acid
SMARCA4 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
  • Interleukin-7 signaling
  • Formation of the beta-catenin:TCF transactivating complex
  • RMTs methylate histone arginines
  • Chromatin modifying enzymes
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination
  • Negative Regulation of CDH1 Gene Transcription
  • Regulation of MITF-M-dependent genes involved in pigmentation
  • Regulation of MITF-M-dependent genes involved in pigmentation
  • Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
  • Formation of the canonical BAF (cBAF) complex
  • Formation of the polybromo-BAF (pBAF) complex
  • Formation of the embryonic stem cell BAF (esBAF) complex
  • Formation of the non-canonical BAF (ncBAF) complex
  • Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
  • Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
SMARCA5 SNF2 related chromatin remodeling ATPase 5
  • NoRC negatively regulates rRNA expression
  • B-WICH complex positively regulates rRNA expression
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Deposition of new CENPA-containing nucleosomes at the centromere
  • Beta-D-Glucose
  • 4-Deoxy-Alpha-D-Glucose
SMC2 structural maintenance of chromosomes 2
  • Condensation of Prophase Chromosomes
  • Condensation of Prometaphase Chromosomes
  • Condensation of Prometaphase Chromosomes
SMC4 structural maintenance of chromosomes 4
  • Condensation of Prophase Chromosomes
  • Condensation of Prometaphase Chromosomes
  • Condensation of Prometaphase Chromosomes
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
  • Signaling by BMP
  • Downregulation of TGF-beta receptor signaling
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
  • Asymmetric localization of PCP proteins
  • Hedgehog 'on' state
  • Hedgehog 'on' state
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX3 expression and activity
  • Antigen processing: Ubiquitination & Proteasome degradation
SNAI1 snail family transcriptional repressor 1
  • Regulation of PTEN gene transcription
  • Regulation of PTEN gene transcription
  • Epithelial-Mesenchymal Transition (EMT) during gastrulation
  • Regulation of CDH11 gene transcription
  • Negative Regulation of CDH1 Gene Transcription
SNRNP200 small nuclear ribonucleoprotein U5 subunit 200
  • mRNA Splicing - Major Pathway
  • mRNA Splicing - Minor Pathway
  • Retinitis pigmentosa (RP)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
  • mRNA Splicing - Major Pathway
  • Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SNRPB2 small nuclear ribonucleoprotein polypeptide B2
  • mRNA Splicing - Major Pathway
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide
  • snRNP Assembly
  • mRNA Splicing - Major Pathway
  • mRNA Splicing - Minor Pathway
  • SARS-CoV-2 modulates host translation machinery
SNTB2 syntrophin beta 2
  • Formation of the dystrophin-glycoprotein complex (DGC)
  • Formation of the dystrophin-glycoprotein complex (DGC)
SNX27 sorting nexin 27
SPOP speckle type BTB/POZ protein
  • Hedgehog 'on' state
  • SPOP-mediated proteasomal degradation of PD-L1(CD274)
SPTAN1 spectrin alpha, non-erythrocytic 1
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Nephrin family interactions
  • NCAM signaling for neurite out-growth
  • NCAM signaling for neurite out-growth
  • Interaction between L1 and Ankyrins
  • Interaction between L1 and Ankyrins
  • RAF/MAP kinase cascade
  • Neutrophil degranulation
  • COPI-mediated anterograde transport
  • RHOU GTPase cycle
  • RHOV GTPase cycle
  • Sensory processing of sound by inner hair cells of the cochlea
  • Sensory processing of sound by outer hair cells of the cochlea
  • Early infantile epileptic encephalopathy; Ohtahara syndrome

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