EGFR - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
PTPRR	protein tyrosine phosphatase receptor type R
PTPRS	protein tyrosine phosphatase receptor type S	ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	Alendronic acid Etidronic acid
PTPRT	protein tyrosine phosphatase receptor type T
PTPRU	protein tyrosine phosphatase receptor type U	Signaling by SCF-KIT
RAB31	RAB31, member RAS oncogene family	Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
RAB3A	RAB3A, member RAS oncogene family	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
RAP1GDS1	Rap1 GTPase-GDP dissociation stimulator 1	RHOT2 GTPase cycle RHOT1 GTPase cycle
RAPGEF1	Rap guanine nucleotide exchange factor 1	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
RASA1	RAS p21 protein activator 1	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases		RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
RGS16	regulator of G protein signaling 16	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
RGS2	regulator of G protein signaling 2	G alpha (q) signalling events
RGS4	regulator of G protein signaling 4	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
RIMS2	regulating synaptic membrane exocytosis 2
RIN1	Ras and Rab interactor 1	RAB GEFs exchange GTP for GDP on RABs
RIN2	Ras and Rab interactor 2	RAB GEFs exchange GTP for GDP on RABs		Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome
RIPK1	receptor interacting serine/threonine kinase 1	Caspase activation via Death Receptors in the presence of ligand TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Ub-specific processing proteases Ovarian tumor domain proteases Dimerization of procaspase-8 TNF signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IKK complex recruitment mediated by RIP1 Potential therapeutics for SARS Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death Defective RIPK1-mediated regulated necrosis	Fostamatinib
RNF115	ring finger protein 115	Antigen processing: Ubiquitination & Proteasome degradation
RNF126	ring finger protein 126	Antigen processing: Ubiquitination & Proteasome degradation
RNF128	ring finger protein 128	Ub-specific processing proteases Ovarian tumor domain proteases
RNF130	ring finger protein 130	Antigen processing: Ubiquitination & Proteasome degradation

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