UBC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
RBMS2	RNA binding motif single stranded interacting protein 2
RC3H2	ring finger and CCCH-type domains 2
RCHY1	ring finger and CHY zinc finger domain containing 1	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
RCOR1	REST corepressor 1	HDACs deacetylate histones Regulation of PTEN gene transcription Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
RECQL	RecQ like helicase
RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
REPIN1	replication initiator 1
REV1	REV1 DNA directed polymerase	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis
RFC1	replication factor C subunit 1	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching
RFWD3	ring finger and WD repeat domain 3
RGPD3	RANBP2 like and GRIP domain containing 3
RGS2	regulator of G protein signaling 2	G alpha (q) signalling events
RHBDD3	rhomboid domain containing 3
RHOF	ras homolog family member F, filopodia associated	Neutrophil degranulation RHOF GTPase cycle
RHOG	ras homolog family member G	GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle
RIF1	replication timing regulatory factor 1	Nonhomologous End-Joining (NHEJ)
RIGI	RNA sensor RIG-I	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions Modulation of host responses by IFN-stimulated genes
RIOK1	RIO kinase 1	Major pathway of rRNA processing in the nucleolus and cytosol	Fostamatinib
RIOK3	RIO kinase 3	Major pathway of rRNA processing in the nucleolus and cytosol	Fostamatinib
RIPK2	receptor interacting serine/threonine kinase 2	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway Downstream TCR signaling p75NTR recruits signalling complexes TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	Fostamatinib

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