UBC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
PTOV1	PTOV1 extended AT-hook containing adaptor protein
PTPN2	protein tyrosine phosphatase non-receptor type 2	Negative regulation of MET activity Interleukin-37 signaling PKR-mediated signaling		Type I diabetes mellitus
PUS7L	pseudouridine synthase 7 like
QSOX2	quiescin sulfhydryl oxidase 2
R3HDM4	R3H domain containing 4
RAB30	RAB30, member RAS oncogene family	Intra-Golgi traffic RAB geranylgeranylation
RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2	COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs		Martsolf syndrome
RABEP1	rabaptin, RAB GTPase binding effector protein 1	TBC/RABGAPs
RAC1	Rac family small GTPase 1	GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Azathioprine ADME Factors involved in megakaryocyte development and platelet production	Dextromethorphan Azathioprine Guanosine-5'-Diphosphate
RAD18	RAD18 E3 ubiquitin protein ligase	Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
RAD23A	RAD23 nucleotide excision repair protein A	Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
RAD23B	RAD23 nucleotide excision repair protein B	N-glycan trimming in the ER and Calnexin/Calreticulin cycle Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
RAG1	recombination activating 1	Interleukin-7 signaling MAPK6/MAPK4 signaling		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
RAMAC	RNA guanine-7 methyltransferase activating subunit
RAP1GDS1	Rap1 GTPase-GDP dissociation stimulator 1	RHOT2 GTPase cycle RHOT1 GTPase cycle
RASAL2	RAS protein activator like 2	Regulation of RAS by GAPs RND3 GTPase cycle RND1 GTPase cycle
RASIP1	Ras interacting protein 1
RASSF8	Ras association domain family member 8
RB1CC1	RB1 inducible coiled-coil 1	Macroautophagy
RBCK1	RANBP2-type and C3HC4-type zinc finger containing 1	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation

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