ESR1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NR2C2	nuclear receptor subfamily 2 group C member 2	Nuclear Receptor transcription pathway
NR2F1	nuclear receptor subfamily 2 group F member 1	Nuclear Receptor transcription pathway	beta-Naphthoflavone
NR2F6	nuclear receptor subfamily 2 group F member 6	Nuclear Receptor transcription pathway
NRIP1	nuclear receptor interacting protein 1	SUMOylation of transcription cofactors Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
NSD1	nuclear receptor binding SET domain protein 1	PKMTs methylate histone lysines		Sotos syndrome and Weaver syndrome Beckwith-Wiedemann syndrome
NSD2	nuclear receptor binding SET domain protein 2	PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint		Multiple myeloma
NSD3	nuclear receptor binding SET domain protein 3	PKMTs methylate histone lysines
NSF	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	1-Ethyl-Pyrrolidine-2,5-Dione
NUDT21	nudix hydrolase 21	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
OTUB1	OTU deubiquitinase, ubiquitin aldehyde binding 1	Ub-specific processing proteases Ovarian tumor domain proteases
P4HB	prolyl 4-hydroxylase subunit beta	Collagen biosynthesis and modifying enzymes Insulin processing Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly LDL remodeling Interleukin-12 signaling Interleukin-23 signaling	Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
PA2G4	proliferation-associated 2G4	Neutrophil degranulation
PAGR1	PAXIP1 associated glutamate rich protein 1	Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
PAK1	p21 (RAC1) activated kinase 1	Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Fostamatinib
PAK6	p21 (RAC1) activated kinase 6	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle	Fostamatinib
PBXIP1	PBX homeobox interacting protein 1
PDIA3	protein disulfide isomerase family A member 3	ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
PELP1	proline, glutamate and leucine rich protein 1	Major pathway of rRNA processing in the nucleolus and cytosol PTK6 Expression
PGC	progastricsin
PGR	progesterone receptor	Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate

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