TK1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CSAD	cysteine sulfinic acid decarboxylase	Degradation of cysteine and homocysteine	Pyridoxal phosphate Cysteine
DACT1	dishevelled binding antagonist of beta catenin 1	Degradation of DVL
DALRD3	DALR anticodon binding domain containing 3
DCAF13	DDB1 and CUL4 associated factor 13	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Neddylation
DDAH2	DDAH family member 2, ADMA-independent		Citrulline
DEAF1	DEAF1 transcription factor
DMPK	DM1 protein kinase	Ion homeostasis	Bisindolylmaleimide VIII	Myotonic dystrophy (DM)
DOCK7	dedicator of cytokinesis 7	MET activates RAP1 and RAC1 CDC42 GTPase cycle RAC1 GTPase cycle Factors involved in megakaryocyte development and platelet production
DRAP1	DR1 associated protein 1	Signaling by NODAL Signaling by Activin
DUS2	dihydrouridine synthase 2	tRNA modification in the nucleus and cytosol PKR-mediated signaling
DYNC1I1	dynein cytoplasmic 1 intermediate chain 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
DYNC2I1	dynein 2 intermediate chain 1	Intraflagellar transport
DYNLT2B	dynein light chain Tctex-type 2B	Intraflagellar transport
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	Eukaryotic Translation Elongation Eukaryotic Translation Elongation Peptide chain elongation HSF1 activation Neutrophil degranulation Protein methylation Chaperone Mediated Autophagy SARS-CoV-1 modulates host translation machinery	Zinc Guanosine-5'-Diphosphate Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
EIF3G	eukaryotic translation initiation factor 3 subunit G	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF4A2	eukaryotic translation initiation factor 4A2	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
EIF6	eukaryotic translation initiation factor 6		Copper
ERG28	ergosterol biosynthesis 28 homolog
EXT2	exostosin glycosyltransferase 2	HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS		Multiple exostoses Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
EZH2	enhancer of zeste 2 polycomb repressive complex 2 subunit	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription	Tazemetostat CPI-1205

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